Document Detail

Reduced exercise capacity in untreated adults with primary growth hormone resistance (Laron syndrome).
MedLine Citation:
PMID:  14974919     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Primary IGF-I deficiency (Laron syndrome, LS) may decrease exercise capacity as a result of a lack of an IGF-I effect on heart, peripheral muscle or lung structure and/or function. METHODS: Eight patients (six females) who had never received treatment with IGF-I, with mean age of 36 +/- 10 (SD) years (range 21-48), weight 47 +/- 9 kg (31-61), height 126 +/- 12 cm (112-140) and body mass index of 29 +/- 4 kg/m2 (24-34), and 12 age-matched controls, underwent lung function tests and incremental cycling to the limit of tolerance (CPX, MedGraphics). Predicted values for the patients were derived from adult equations based on height. RESULTS: In LS patients, lung function was near normal; vital capacity was 84 +/- 11% of expected (66-103). Peak exercise O2-uptake and the anaerobic threshold were reduced, 57 +/- 20% of predicted and 33 +/- 9% of predicted peak (P = 0.005 vs. controls), despite normal mean exercise breathing reserve. All parameters were normal in the controls. CONCLUSION: Exercise capacity in untreated adults with LS is significantly reduced. The limitation for most patients was not ventilatory but resulted either from low cardiac output and/or from dysfunction of the peripheral muscles. However, the relative contribution of each of these elements and/or the role of poor fitness needs further study.
Issahar Ben-Dov; Mark Gaides; Mickey Scheinowitz; Rivka Wagner; Zvi Laron
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical endocrinology     Volume:  59     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-02-25     Completed Date:  2004-03-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  763-7     Citation Subset:  IM    
The Pulmonary Institute, Sheba Medical Center, Tel-Hashomer, Israel.
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MeSH Terms
Case-Control Studies
Exercise Test
Exercise Tolerance*
Growth Hormone / metabolism*
Heart Rate
Insulin-Like Growth Factor I / deficiency*
Middle Aged
Oxygen / blood
Respiratory Function Tests
Reg. No./Substance:
67763-96-6/Insulin-Like Growth Factor I; 7782-44-7/Oxygen; 9002-72-6/Growth Hormone

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