Document Detail


Reduced erythrocyte superoxide dismutase activity in low birth weight infants given iron supplements.
MedLine Citation:
PMID:  2034479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Erythrocyte superoxide dismutase (ESOD) activity reflects copper utilization and the risk of copper deficiency. To investigate the possible effects of inorganic iron on the metabolism of copper in low birth weight infants, we have measured ESOD activities in three groups of infants receiving different iron supplements. Fifty-five low birth weight infants were randomly assigned to receive daily from 28 d either 13.8 mg (HiFe), 7 mg (MidFe), or no elemental iron (NatFe) as iron edetate. At 27 d, 8, 12, and 20 wk postnatal age, infants were weighed and measured and hematologic indices, plasma ferritin, zinc, and copper concentrations, and ESOD activities were assayed. Anthropometrical and hematologic indices and plasma copper and zinc concentrations did not differ among treatment groups at any time, but at 20 wk, plasma ferritin concentrations [(micrograms/L) mean; SD] were lower in the NatFe group (17; 2.0) than in the HiFe group (32; 1.9: 95% confidence interval for mean difference 6.6 to 22.0, p less than 0.01). ESOD activities (U/g Hb) were similar in HiFe (1447; 263), MidFe (1552; 322), and NatFe (1538; 382) groups at 27 d, but by 20 wk activities in the HiFe group (1537; 211) were lower than in the MidFe (1789; 403: 95% confidence interval 38 to 466, p less than 0.05) and NatFe (1858; 304: 95% confidence interval 150 to 492, p less than 0.01) groups. The lower ESOD activities found in the HiFe group at 20 wk may reflect altered copper metabolism induced by the iron supplement, but the clinical importance of this observation is unknown.
Authors:
S M Barclay; P J Aggett; D J Lloyd; P Duffty
Related Documents :
8523189 - Hypercalcemia and nephrocalcinosis in patients with congenital lactase deficiency.
9183479 - Evaluation of full-term infants fed an evaporated milk formula.
8213099 - Relationship between iron status in pregnant women and their newborn babies. investigat...
22126419 - Establishment and development of intestinal microbiota in preterm neonates.
1503059 - Effect of a zinc-fortified formula on immunocompetence and growth of malnourished infants.
3297709 - "peripheral" tetrahydrobiopterin deficiency with hyperphenylalaninaemia due to incomple...
8523189 - Hypercalcemia and nephrocalcinosis in patients with congenital lactase deficiency.
15159699 - How much tachycardia in infants can be attributed to fever?
3421279 - The use of antenatal vitamin k in the prevention of early neonatal intraventricular hem...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  29     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-06-24     Completed Date:  1991-06-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  297-301     Citation Subset:  IM    
Affiliation:
Department of Child Health, University of Aberdeen, Scotland, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Copper / blood,  deficiency,  metabolism*
Erythrocytes / enzymology*
Ferritins / metabolism
Humans
Infant, Low Birth Weight
Infant, Newborn
Iron / administration & dosage*
Superoxide Dismutase / blood*
Zinc / blood
Chemical
Reg. No./Substance:
7439-89-6/Iron; 7440-50-8/Copper; 7440-66-6/Zinc; 9007-73-2/Ferritins; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Failure of premature rabbits to increase antioxidant enzymes during hyperoxic exposure: increased su...
Next Document:  Hematopoietic cell transplantation after administration of high-dose busulfan in murine globoid cell...