| Reduced epinephrine reserve in response to insulin-induced hypoglycemia in patients with pituitary adenoma. | |
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MedLine Citation:
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PMID: 17766707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Hypoglycemia induces rapid secretion of counterregulatory hormones such as catecholamine, glucagon, cortisol, and GH. Insulin-induced hypoglycemia is used for evaluating GH-IGF-I and ACTH-adrenal axes in patients with pituitary disorders. The aim of this study was to determine whether the response of catecholamine secretion to hypoglycemia is disrupted in patients with pituitary adenoma. METHODS: The study population comprised 23 patients with pituitary adenoma (non-functioning adenoma or prolactinoma). An insulin tolerance test was performed and serum catecholamines as well as plasma GH and serum cortisol were measured. RESULTS: The study patients showed diminished response of plasma epinephrine to insulin-induced hypoglycemia. With the cutoff level of peak epinephrine for defining severe impairment set at 400 pg/ml, more patients with secondary adrenal insufficiency showed severe impairment of the epinephrine response than did those without it. Peak epinephrine levels to insulin-induced hypoglycemia were significantly correlated with peak cortisol levels. In patients with secondary hypothyroidism, secondary hypogonadism, GH deficiency, or diabetes insipidus, the prevalence of severe impairment of the epinephrine response was similar to that in patients without these deficiencies. CONCLUSIONS: Impaired epinephrine secretion in response to insulin-induced hypoglycemia was frequently observed in patients with pituitary adenoma. This disorder was especially severe in patients with secondary adrenal insufficiency. |
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Authors:
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Shinya Morita; Michio Otsuki; Maki Izumi; Nobuyuki Asanuma; Shuichi Izumoto; Youichi Saitoh; Toshiki Yoshimine; Soji Kasayama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 157 ISSN: 0804-4643 ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-09-03 Completed Date: 2007-11-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 265-70 Citation Subset: IM |
Affiliation:
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Department of Medicine, Osaka University Graduate School of Medicine, Yamada-Oka, Suita, Osaka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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blood*,
complications,
diagnosis Adrenal Insufficiency / blood*, diagnosis, etiology Adult Aged Biological Markers / blood Epinephrine / blood* Female Humans Hypoglycemia / blood*, chemically induced Hypoglycemic Agents / diagnostic use Insulin / diagnostic use Male Middle Aged Norepinephrine / blood Pituitary Neoplasms / blood*, complications, diagnosis Prolactinoma / blood, complications, diagnosis Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Hypoglycemic Agents; 11061-68-0/Insulin; 51-41-2/Norepinephrine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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