| Reduced effectiveness of escitalopram in the forced swimming test is associated with increased serotonin clearance rate in food-restricted rats. | |
| | |
MedLine Citation:
|
PMID: 19419596 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Efficacy of antidepressant drugs is often limited. One of the limiting factors may be diet. This study shows that the effect of escitalopram in the forced swimming test is diminished in rats by food restriction that decreased body weight by 8%. The primary target for escitalopram is the serotonin (5-HT) transporter. Using high-speed chronoamperometry to measure 5-HT clearance in vivo in rats fed the same food-restricted diet, the rate of 5-HT clearance from extracellular fluid in brain was dramatically increased. Increased 5-HT transporter function under conditions of dietary restriction might contribute to the decreased effect of escitalopram. These results suggest that diet plays an integral role in determining efficacy of antidepressant drugs, and might well generalize to other psychoactive drugs that impinge upon the 5-HT transporter. |
| | |
Authors:
|
Charles P France; Jun-Xu Li; William A Owens; Wouter Koek; Glenn M Toney; Lynette C Daws |
Related Documents
:
|
9776486 - Effects of level of food intake on ovarian follicle number, size and steroidogenic capa... 7861246 - Activities of antioxidant enzymes in various tissues of male fischer 344 rats are alter... 20035776 - Can overeating induce conditioned taste avoidance in previously food restricted rats? 6632996 - The anti-aging action of hypophysectomy in hypothalamic obese rats: effects on collagen... 16131266 - How many dimensions underlie judgments of learning and recall? evidence from state-trac... 20020276 - Explaining postnatal growth plasticity in a generalist brood parasite. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-05-07 |
Journal Detail:
|
Title: The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) Volume: 12 ISSN: 1469-5111 ISO Abbreviation: Int. J. Neuropsychopharmacol. Publication Date: 2009 Jul |
Date Detail:
|
Created Date: 2009-06-10 Completed Date: 2009-08-18 Revised Date: 2013-03-14 |
Medline Journal Info:
|
Nlm Unique ID: 9815893 Medline TA: Int J Neuropsychopharmacol Country: England |
Other Details:
|
Languages: eng Pagination: 731-6 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229, USA. france@uthscsa.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Animals Brain / drug effects*, metabolism* Chromatography, High Pressure Liquid / methods Citalopram / pharmacology* Electrochemistry / methods Food Deprivation / physiology* Immobility Response, Tonic / drug effects Male Rats Rats, Sprague-Dawley Serotonin / metabolism* Serotonin Uptake Inhibitors / pharmacology* Swimming* Water / metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
DA17918/DA/NIDA NIH HHS; HL71645/HL/NHLBI NIH HHS; K05 DA017918/DA/NIDA NIH HHS; MH64489/MH/NIMH NIH HHS; R01 HL071645/HL/NHLBI NIH HHS; R01 MH064489/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Serotonin Uptake Inhibitors; 50-67-9/Serotonin; 59729-33-8/Citalopram; 7732-18-5/Water |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Remission in schizophrenia: 196-week, double-blind treatment with ziprasidone vs. haloperidol.
Next Document: Development and pilot testing of a feasible, reliable, and valid operative competency assessment too...