Document Detail


Reduced effectiveness of escitalopram in the forced swimming test is associated with increased serotonin clearance rate in food-restricted rats.
MedLine Citation:
PMID:  19419596     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Efficacy of antidepressant drugs is often limited. One of the limiting factors may be diet. This study shows that the effect of escitalopram in the forced swimming test is diminished in rats by food restriction that decreased body weight by 8%. The primary target for escitalopram is the serotonin (5-HT) transporter. Using high-speed chronoamperometry to measure 5-HT clearance in vivo in rats fed the same food-restricted diet, the rate of 5-HT clearance from extracellular fluid in brain was dramatically increased. Increased 5-HT transporter function under conditions of dietary restriction might contribute to the decreased effect of escitalopram. These results suggest that diet plays an integral role in determining efficacy of antidepressant drugs, and might well generalize to other psychoactive drugs that impinge upon the 5-HT transporter.
Authors:
Charles P France; Jun-Xu Li; William A Owens; Wouter Koek; Glenn M Toney; Lynette C Daws
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-05-07
Journal Detail:
Title:  The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)     Volume:  12     ISSN:  1469-5111     ISO Abbreviation:  Int. J. Neuropsychopharmacol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-10     Completed Date:  2009-08-18     Revised Date:  2013-03-14    
Medline Journal Info:
Nlm Unique ID:  9815893     Medline TA:  Int J Neuropsychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  731-6     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229, USA. france@uthscsa.edu
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Brain / drug effects*,  metabolism*
Chromatography, High Pressure Liquid / methods
Citalopram / pharmacology*
Electrochemistry / methods
Food Deprivation / physiology*
Immobility Response, Tonic / drug effects
Male
Rats
Rats, Sprague-Dawley
Serotonin / metabolism*
Serotonin Uptake Inhibitors / pharmacology*
Swimming*
Water / metabolism
Grant Support
ID/Acronym/Agency:
DA17918/DA/NIDA NIH HHS; HL71645/HL/NHLBI NIH HHS; K05 DA017918/DA/NIDA NIH HHS; MH64489/MH/NIMH NIH HHS; R01 HL071645/HL/NHLBI NIH HHS; R01 MH064489/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 50-67-9/Serotonin; 59729-33-8/Citalopram; 7732-18-5/Water
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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