| Reduced drug elimination in congestive heart failure. Studies using aminopyrine as a model drug. | |
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MedLine Citation:
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PMID: 686023 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aminopyrine disposition was studied in 11 patients with congestive heart failure (CHF) and 15 control patients. The aminopyrine metabolic clearance rate was 29.7 +/- 7.1 ml/min (mean +/- SEM) in the patients with CHF and 125.1 +/- 5.7 ml/min (mean +/- SEM) in the control patients (p less than 0.01). The aminopyrine breath test was 2.6 +/- 0.4 per cent (mean +/- SEM) in the patients with CHF and 5.6 +/- 0.3 per cent (mean +/- SEM) in the control subjects (p less than 0.01). Probably due to fluid retention in CHF, the apparent volume of distribution of aminopyrine increased to 63.3 +/- 4.9 liters (mean +/- SEM) in patients with CHF from 43.1 +/- 1.9 liters (mean +/- SEM) in control patients, thereby further impairing aminopyrine elimination in patients with CHF (p less than 0.01). The aminopyrine breath test was measured in a group of eight patients before treatment for an acute episode of CHF and seven to 10 days after initiation of therapy: in each patient clinical improvement was associated with an increased aminopyrine breath test, mean values of aminopyrine breath test increasing from 2.8 per cent before treatment to 5.2 per cent after initiation of treatment (p less than 0.01). These results suggest that in patients with CHF hepatic drug-metabolizing activity is imparied, and the volume of distribution of drugs is increased, with consequent retardation in rates of drug elimination. |
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Authors:
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G W Hepner; E S Vesell; K R Tantum |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The American journal of medicine Volume: 65 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1978 Aug |
Date Detail:
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Created Date: 1978-10-25 Completed Date: 1978-10-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 371-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aminopyrine / metabolism*, therapeutic use Biological Availability Biotransformation Breath Tests Female Heart Failure / drug therapy, metabolism* Humans Liver / metabolism Male Metabolic Clearance Rate Middle Aged Models, Biological Time Factors |
| Chemical | |
Reg. No./Substance:
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58-15-1/Aminopyrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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