Document Detail

Reduced development of cerebral cortex in extremely preterm infants.
MedLine Citation:
PMID:  11030298     Owner:  NLM     Status:  MEDLINE    
Most growth in cortical connections and complexity occurs after 25 weeks. The cerebral cortex of extremely preterm infants when imaged at gestational age 38-42 weeks had less cortical surface area and was less complex than in normal infants born around term (p<0.0148 and p<0.0002, respectively), despite similar term-corrected cerebral tissue volumes. Since deficits acquired during critical periods of brain development may be permanent, these results suggest a neural substrate for the neurocognitive impairment that is frequent among such preterm infants.
M Ajayi-Obe; N Saeed; F M Cowan; M A Rutherford; A D Edwards
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Publication Detail:
Type:  Letter    
Journal Detail:
Title:  Lancet     Volume:  356     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-24     Completed Date:  2000-10-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1162-3     Citation Subset:  AIM; IM    
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MeSH Terms
Cerebral Cortex / growth & development*
Gestational Age
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight*
Magnetic Resonance Imaging

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