Document Detail

Reduced deformability of erythrocytes as feature of congenital dyserythropoietic anaemia type II (HEMPAS).
MedLine Citation:
PMID:  10711781     Owner:  NLM     Status:  MEDLINE    
In this study we report results regarding erythrocytes deformability in congenital dyserythropoietic anemia type II (HEMPAS) by the use of LORCA (Laser-assisted Optical Rotational Cell Analyzer). The reduced erythrocytes deformability observed in seven case of CDA II is caused by changes in the structure of glycoproteins due to the incomplete glycosylation of erythrocytic and erythroblastic membrane. Erythrocytes deformability (EI) was shown to be inversely related with mean corpuscular volume (MCV) and mean haemoglobin concentration (MCH).
P Izzo; A Spagnuolo; A Manicone; P Nazzaro; V M Lauta
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical hemorheology and microcirculation     Volume:  21     ISSN:  1386-0291     ISO Abbreviation:  Clin. Hemorheol. Microcirc.     Publication Date:  1999  
Date Detail:
Created Date:  2000-04-07     Completed Date:  2000-04-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9709206     Medline TA:  Clin Hemorheol Microcirc     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  425-30     Citation Subset:  IM    
DIMO, Biomedical Science and Human Oncology, University of Bari, Italy.
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MeSH Terms
Anemia, Dyserythropoietic, Congenital / blood*
Erythrocyte Deformability*
Erythrocyte Indices
Erythrocytes / metabolism,  pathology*,  ultrastructure
Hemoglobins / metabolism
Middle Aged
Optical Rotation
Reg. No./Substance:

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