Document Detail

Reduced daytime intramuscular blood flow in patients with restless legs syndrome/Willis-Ekbom disease (RLS/WED).
MedLine Citation:
PMID:  24521165     Owner:  NLM     Status:  Publisher    
AIM: The aim of this study was to examine possible signs of impairment of the microcirculation in the lower extremities of female patients suffering from primary restless legs syndrome/Willis-Ekbom disease.
METHODS: This study was performed in eight female patients, mean age 48 years (range 21-65), diagnosed with primary restless legs syndrome but otherwise healthy. Eight healthy female control subjects, mean age 47 years (range 27-64), were also included in the study. Laser Doppler flowmetry was used to determine intramuscular blood flow by placing an optical single fibre in the tibialis anterior muscle belly. The studies were performed between 8-10 AM and 8-10 PM. Blood flow was expressed in perfusion units.
RESULTS: The median intramuscular blood flow in the restless legs syndrome-patients' tibialis anterior muscle, recorded from both legs, was significantly higher in the morning, 17.9 perfusion units, than in the evening, 12.1 perfusion units (P=0.004). Corresponding values for the healthy controls were 13.1 perfusion units and 12.0 perfusion units, a non-significant difference. The relative fold changes of microcirculation in the RLS group compared to healthy age matched controls were 0.7 ± 0.3 and 1.1 ± 0.6 respectively, P = 0.04.
CONCLUSION: Our results suggest that in female patients with primary restless legs syndrome, the microcirculation in the tibialis anterior muscle is higher in the morning compared with in the evening.
Eva Oskarsson; Britta Wåhlin-Larsson; Jan Ulfberg
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-13
Journal Detail:
Title:  Psychiatry and clinical neurosciences     Volume:  -     ISSN:  1440-1819     ISO Abbreviation:  Psychiatry Clin. Neurosci.     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-2-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9513551     Medline TA:  Psychiatry Clin Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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