Document Detail


Reduced cortisol latency in depressive illness.
MedLine Citation:
PMID:  6838331     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Depressed patients commonly have disturbances in their sleep and cortisol secretory patterns. When the sleep-related changes in plasma cortisol concentration were measured in 14 patients with a primary major depressive illness, they differed significantly from the changes measured in 14 age- and sex-matched healthy control subjects. The nadir of the nocturnal plasma cortisol concentration was significantly greater in the group of depressed patients, and the nocturnal increase in the plasma cortisol concentration occurred significantly closer to sleep onset in these patients. The circadian activity within the hypothalamic-pituitary-adrenal axis of these depressed patients showed a subtle but significantly disturbed temporal relationship to sleep onset. This reduced time between sleep onset and the nocturnal increase in cortisol secretion suggests a possible biologic correlate of a depressive illness that might be useful as an illness marker in depressed patients.
Authors:
D B Jarrett; P A Coble; D J Kupfer
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of general psychiatry     Volume:  40     ISSN:  0003-990X     ISO Abbreviation:  Arch. Gen. Psychiatry     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-05-27     Completed Date:  1983-05-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372435     Medline TA:  Arch Gen Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  506-11     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Circadian Rhythm
Depressive Disorder / blood*,  physiopathology,  psychology
Female
Humans
Hydrocortisone / blood*,  secretion
Hypothalamo-Hypophyseal System / physiopathology
Male
Middle Aged
Pituitary-Adrenal System / physiopathology
Psychiatric Status Rating Scales
Sleep / physiology*
Sleep, REM / physiology
Grant Support
ID/Acronym/Agency:
MH-00327/MH/NIMH NIH HHS; MH-24652/MH/NIMH NIH HHS; MH-30915/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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