Document Detail


Reduced conscious blood flow in the stomach during non-steroidal anti-inflammatory drugs administration assessed by flash echo imaging.
MedLine Citation:
PMID:  17710668     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Harmonic flash echo imaging, which is an intermittent second harmonic imaging technique, has recently been developed for the evaluation of blood flow. The present study was designed to investigate human gastric blood flow during administration of non-steroidal anti-inflammatory drugs (NSAIDs) by harmonic flash echo imaging. MATERIAL AND METHODS: Eight healthy volunteers were enrolled in the study. After an overnight fast, the volunteers were requested to drink 400 ml water and remain in the sitting position. Seven milliliters (300 mg/ml) Levovist (SHU508A) was then injected intravenously at the rate of 1 ml/s, and intermittent harmonic scanning was carried out at 1-s intervals. A similar examination was carried out one hour after each subject took an oral tablet of diclofenac sodium (50 mg). To minimize the effect of variations in acoustic attenuation among patients, the ratio of the maximum amplitude in the gastric wall to that in the portal vein was expressed as the gastric perfusion index. RESULTS: Strong ultrasonographic contrast enhancement of the gastric wall and portal vein was observed. The area under the curve was significantly reduced in the images obtained after ingestion of the diclofenac sodium tablet. The gastric perfusion index was significantly reduced from 0.617+/-0.114 to 0.480+/-0.127 in the antrum and from 0.659+/-0.103 to 0.509+/-0.107 in the lower gastric corpus after ingestion of the diclofenac sodium tablet (p<0.05). CONCLUSIONS: A reduction in the human conscious gastric transmural blood flow following ingestion of an NSAID is revealed by harmonic flash echo imaging.
Authors:
Toshihiro Nishizawa; Hidekazu Suzuki; Tatsuhiro Masaoka; Eisuke Iwasaki; Toshifumi Hibi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  42     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-21     Completed Date:  2008-02-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1040-4     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine Keio University School of Medicine, Eiju General Hospital, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Area Under Curve
Contrast Media
Diclofenac / pharmacology*
Female
Humans
Image Enhancement
Male
Microbubbles
Middle Aged
Polysaccharides / diagnostic use
Portal Vein / drug effects,  ultrasonography
Regional Blood Flow / drug effects,  physiology
Stomach / blood supply*,  ultrasonography
Ultrasonography, Doppler / methods
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Contrast Media; 0/Polysaccharides; 127279-08-7/SHU 508; 15307-86-5/Diclofenac

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