Document Detail


Reduced concentration of serum growth hormone-binding protein in children with idiopathic short stature. National Cooperative Growth Study.
MedLine Citation:
PMID:  8200933     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One possible explanation for the growth failure in children with idiopathic short stature (ISS) is reduced peripheral responsiveness to GH. In Laron syndrome, growth retardation is caused by GH resistance due to GH receptor (GH-R) defects, which are associated in most cases with absent or low serum concentrations of the GH-R-related GH-binding protein (GHBP). We tested the hypothesis that some children with ISS have reduced serum concentrations of GHBP and that this may reflect decreased sensitivity to GH. A ligand-mediated immunofunctional assay was used to measure biochemically active GHBP in serum from 1549 children, including 773 controls, 573 with ISS, 107 with GH deficiency (GHD), and 96 with Turner syndrome (TS). Ages ranged from 1-17 yr. Serum GHBP concentrations in children with GHD, ISS, and TS were converted to SD scores and compared to controls by analysis of variance. In male and female ISS subjects, approximately 90% had GHBP concentrations below the age- and sex-adjusted mean for controls, and 20% had GHBP concentrations below the normal range. The mean serum GHBP SD score was lower in both males and females with GHD (-0.6) or ISS (-1.2) than in controls (both P < 0.005). The mean for ISS males was significantly lower than that for GHD males (P < 0.0001). The mean GHBP SD score for girls with TS (-0.3) did not differ significantly from that of the control females. The decreased levels of serum GHBP in some children with idiopathic short stature suggest that these children could have a defect at the level of the GH-R.
Authors:
L M Carlsson; K M Attie; P G Compton; R V Vitangcol; T J Merimee
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  78     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-07-05     Completed Date:  1994-07-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1325-30     Citation Subset:  AIM; IM    
Affiliation:
Genetech, Inc., South San Francisco, California 94080.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Biological Markers / blood
Body Height
Body Mass Index
Carrier Proteins / blood*
Child
Child, Preschool
Female
Growth Disorders / blood*
Growth Hormone / blood*,  deficiency
Humans
Insulin-Like Growth Factor I / analysis,  metabolism
Male
Reference Values
Sex Factors
Turner Syndrome / blood
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Carrier Proteins; 0/somatotropin-binding protein; 67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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