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Reduced circulating endothelial progenitor cells in the coronary slow flow phenomenon.
MedLine Citation:
PMID:  23196377     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: Endothelial progenitor cells (EPCs) are important for maintaining the normal function and structure of endothelial cells. We tested the hypothesis that patients with coronary slow flow (CSF) have reduced circulating EPCs that may contribute to the pathogenesis of the CSF phenomenon. MATERIALS AND METHODS: Twenty patients with angiographically proven normal coronary flow (the control group; mean age=55.6±8.2 years) and 20 patients with angiographically proven CSF in any coronary artery (the patient group; mean age=56.6±9.7 years) were included in the study. The thrombolysis in myocardial infarction (TIMI) frame count technique was used to document the coronary flow rates for all of the patients. Ficoll density gradient centrifugation was used to isolate mononuclear cells from peripheral blood cells. An inverted fluorescence microscope and direct fluorescent antibody staining were used to identify EPCs. RESULTS: The number of EPCs was significantly reduced in the CSF patient group compared with the control group (36.95±6.1 vs. 53.95±6.7 EPCs/×200 field, P<0.01). A multivariate stepwise regression showed a significant negative correlation between the mean TIMI frame counts and the numbers of EPCs (regression coefficient B=-0.65, P<0.01). CONCLUSION: The number of EPCs was reduced and correlated negatively with the TIMI frame count in the CSF patients. Reduced EPCs may be associated with the pathophysiological process of CSF phenomenon.
Authors:
Quanzhong Li; Jinjie Han; Hua Chen; Xinling Mo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-27
Journal Detail:
Title:  Coronary artery disease     Volume:  -     ISSN:  1473-5830     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Cardiology, The Affiliated Hospital of Guilin Medical College, Guangxi, China.
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