Document Detail


Reduced circulating angiogenic cells in Alzheimer disease.
MedLine Citation:
PMID:  19470969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Neurovascular dysfunction and senescent endothelium contribute to the progression of Alzheimer disease (AD). Circulating angiogenic cells (CACs), such as endothelial progenitor cells (EPCs), provide a cellular reservoir for the endothelial replacement. To study the involvement of CACs in AD pathogenesis, we investigated the levels of CACs in patients with AD. METHODS: Consecutive patients with newly diagnosed AD (n = 55), patients with non-AD neurodegenerative diseases (n = 37), and nondemented risk factor control subjects (RF control, n = 55 and 37) were enrolled after matching for age, sex, and Framingham risk score. Peripheral blood samples were taken, and EPC colony-forming units (CFU-EPC) were cultured and counted. RESULTS: The patients with AD had significantly lower CFU-EPC than the RF controls. In the patients with AD, a lower CFU-EPC was independently associated with either a lower Mini-Mental State Examination score or a higher Clinical Dementia Rating scale score, indicating a greater reduction in CFU-EPC in advanced AD. Patients with non-AD neurodegenerative diseases did not show a significant decrease in CFU-EPC levels. CONCLUSION: Our results indicate that patients with Alzheimer disease (AD) have reduced circulating angiogenic cells, suggesting that an abnormal capacity to regenerate endothelium is associated with AD.
Authors:
S-T Lee; K Chu; K-H Jung; H-K Park; D-H Kim; J-J Bahn; J-H Kim; M-J Oh; S K Lee; M Kim; J-K Roh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  72     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-27     Completed Date:  2009-06-25     Revised Date:  2010-01-27    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1858-63     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology, Seoul National University Hospital, 101, Daehangno, Jongno-Gu, Seoul 110-744, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / blood*,  complications,  physiopathology,  psychology
Cell Count
Cognition
Cognition Disorders / blood,  complications,  psychology
Colony-Forming Units Assay
Endothelial Cells / cytology*
Female
Flow Cytometry
Humans
Linear Models
Logistic Models
Male
Multivariate Analysis
Neovascularization, Physiologic*
Neurodegenerative Diseases / blood
Severity of Illness Index
Stem Cells / cytology*
Comments/Corrections
Comment In:
Neurology. 2010 Jan 26;74(4):346; author reply 346-7   [PMID:  20101043 ]
Erratum In:
Neurology. 2009 Aug 18;73(7):573

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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