Document Detail

Reduced cingulate glutamate/glutamine-to-creatine ratios in adult patients with attention deficit/hyperactivity disorder -- a magnet resonance spectroscopy study.
MedLine Citation:
PMID:  17303167     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The dopaminergic system is thought to be essentially involved in the pathogenesis of attention deficit/hyperactivity disorder (ADHD). However, there is also evidence for abnormalities in the glutamatergic system and recent theories focus on a disturbed interaction between the two systems as the essential pathogenetic mechanism of ADHD. In the present study, we wanted to test the hypothesis that prefrontal glutamate signals indirectly indicate dopaminergic dysfunction in adult patients with ADHD. METHODS: Twenty-eight adult patients with ADHD and 28 group-matched healthy volunteers were studied clinically and using chemical-shift MR spectroscopy (MRS) of the prefrontal cortex covering the anterior cingulate gyrus. RESULTS: A significant reduction of the combined glutamate/glutamine to creatine ratio in the right anterior cingulate cortex in patients with ADHD was found. DISCUSSION: Glutamatergic alterations as measured with MRS might play a role in the pathogenesis of adult patients with ADHD.
E Perlov; A Philipsen; B Hesslinger; M Buechert; J Ahrendts; B Feige; E Bubl; J Hennig; D Ebert; L Tebartz van Elst
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Publication Detail:
Type:  Journal Article     Date:  2007-02-15
Journal Detail:
Title:  Journal of psychiatric research     Volume:  41     ISSN:  0022-3956     ISO Abbreviation:  J Psychiatr Res     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-08-21     Completed Date:  2007-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376331     Medline TA:  J Psychiatr Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  934-41     Citation Subset:  IM    
University Hospital of Freiburg, Department of Psychiatry, Hauptstrasse 5, 79104 Freiburg, Germany.
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MeSH Terms
Aspartic Acid / analogs & derivatives,  metabolism
Attention Deficit Disorder with Hyperactivity / diagnosis,  physiopathology*
Choline / metabolism
Creatine / metabolism*
Dominance, Cerebral / physiology
Dopamine / physiology
Glutamic Acid / metabolism*
Glutamine / metabolism*
Gyrus Cinguli / physiopathology*
Inositol / metabolism
Magnetic Resonance Spectroscopy*
Prefrontal Cortex / physiopathology
Reg. No./Substance:
56-84-8/Aspartic Acid; 56-85-9/Glutamine; 56-86-0/Glutamic Acid; 57-00-1/Creatine; 62-49-7/Choline; 6917-35-7/Inositol; 997-55-7/N-acetylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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