| Reduced chronotropic reserve to the metabolic requirement during exercise in advanced heart failure with old myocardial infarction. | |
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MedLine Citation:
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PMID: 3599368 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the metabolic and cardiac responses to exercise by expiratory gas analysis in 40 patients with old myocardial infarction and 33 normal sedentary males. On the basis of exercise energy metabolism, the elevation of the respiratory quotient (RQ; RQ = VCO2/VO2) during exercise is caused by the increase of blood lactate due to the augmented anaerobic metabolism. Functional aerobic impairment (FAI) in our study was significantly advanced in the control group and the NYHA functional class I, class II and class III groups, that is, -2.3 +/- 11.2%, +14.8 +/- 10.4%, +27.8 +/- 13.8% and +49.4 +/- 2.8%, respectively. The delta RQ values were similar among all groups; 0.29 respectively. The delta RQ values were similar among all groups; 0.29 +/- 0.06, 0.28 +/- 0.07, 0.27 +/- 0.07 and 0.29 +/- 0.09, respectively. Functional chronotropic impairment (FCI) for the same groups was -0.9 +/- 7.0%, +1.4 6.1%, +3.8 +/- 4.8% and +8.7 +/- 6.0%, and that of the class III group was significantly larger than that of the control group. Thus, in the class III congestive heart failure group, the chronotropic response to the metabolic requirement was impaired in comparison to the control group. It was concluded that the reduced chronotropic reserve was present in NYHA class III patients with old myocardial infarction, and that this mechanism might contribute to a decrease in the pump reserve of the heart, resulting in further impairment of physical capacity in these patients. |
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Authors:
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H Yamabe; K Kobayashi; T Takata; H Fukuzaki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese circulation journal Volume: 51 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 1987 Mar |
Date Detail:
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Created Date: 1987-08-17 Completed Date: 1987-08-17 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 259-64 Citation Subset: IM; S |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cardiac Output Energy Metabolism* Heart / physiology Heart Failure / metabolism*, physiopathology Heart Rate* Humans Male Middle Aged Myocardial Infarction / metabolism*, physiopathology Myocardium / metabolism* Oxygen Consumption Physical Exertion* Respiration |
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