Document Detail

Reduced cerebral perfusion in elderly men with silent myocardial ischaemia and nocturnal blood pressure dipping.
MedLine Citation:
PMID:  21111419     Owner:  NLM     Status:  In-Process    
OBJECTIVE: Knowledge about the impact of cardiovascular disease on cerebral autoregulation and cognition in aging is sparse. The aim of our study is to examine the association between cerebral blood flow (CBF), silent ST segment depression (STDE) on ambulatory ECG (LTER) and nocturnal blood pressure variations in elderly men.
METHODS: In a cross-sectional cohort study "Men born in 1914", eighty 83-year-old men were examined by CBF, LTER and ambulatory blood pressure monitoring (ABPM). The presence and the degree of STDE were analyzed in relation to regional CBF in nocturnal blood pressure dippers/non-dippers.
RESULTS: Fourty-five (56%) study subjects had STDE, 25 at both day and night and 20 only daytime. Subjects with STDE expressed lower CBF in left frontal, temporal, inferior parietal regions and bilateral superior parietal regions compared to men without STDE. Low regional CBF was most frequent in subjects with daytime STDE. Subjects with nocturnal diastolic blood pressure dip and STDE (22 subjects; 35%) had lower mean CBF in the parietal lobe and also correlation between STDE and CBF (r=0.31-0.44, p=0.056-0.006) compared to non-dippers with STDE. The lowest CBF in nocturnal dippers was observed in subjects with maximal STDE daytime.
CONCLUSION: Silent myocardial ischemia may contribute to cerebrovascular disease in non-demented elderly men. Cerebral perfusion seems to be most vulnerable to myocardial ischemia in elderly with nocturnal blood pressure dipping.
Linda Furuäng; Arkadiusz Siennicki-Lantz; Sölve Elmståhl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-05
Journal Detail:
Title:  Atherosclerosis     Volume:  214     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  231-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Department of Health Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
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