| Reduced cerebral blood flow in older men with higher levels of blood pressure. | |
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MedLine Citation:
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PMID: 20408259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine relations of blood pressure (BP) with single photon emission computed tomography (SPECT)-derived estimates of cerebral blood flow in older men and women. METHODS: Seventy-four stroke and dementia-free, community-dwelling older adults (ages 54-83 years; 68% men; 91% white) free of major medical, neurological, or psychiatric disease, engaged in clinical assessment of resting SBP and DBP, MRI rated for brain atrophy, and brain single photon emission computed tomography (SPECT) studies with computerized coding of cortical and select subcortical regions of interest. RESULTS: Given significant interactions of BP and sex with respect to multiple SPECT outcomes, sex-stratified multiple regression models were computed. Models were adjusted for age, fasting glucose levels, antihypertensive medication, BMI, and MRI ratings of brain atrophy. In men (n = 50), higher levels of SBP and/or DBP were associated significantly with lower estimates of cerebral perfusion in the right and left frontal, temporal, parietal, and occipital cortex, thalamus, head of caudate, and cingulate cortex accounting for up to 28% of the variance in these measures (P < 0.05). In women (n = 24), higher DBP was related marginally to higher levels of perfusion in the right temporal cortex (P = 0.05). CONCLUSION: Higher resting SBP or DBP was associated with lower levels of cerebral perfusion in otherwise healthy older men, but not women, in the present sample. Reduced cerebral blood flow may play a pathogenic role in increasing risk for stroke, dementia, and/or cognitive decline, particularly among older men with high BP. |
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Authors:
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Shari R Waldstein; David M Lefkowitz; Eliot L Siegel; William F Rosenberger; Robert J Spencer; Carol F Tankard; Zorayr Manukyan; Evie J Gerber; Leslie Katzel |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of hypertension Volume: 28 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-20 Completed Date: 2010-07-29 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 993-8 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of Maryland, Baltimore County, Baltimore, MD 21250, USA. waldstei@umbc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Atrophy Blood Flow Velocity / physiology Blood Pressure / physiology* Brain / pathology, radionuclide imaging Cerebrovascular Circulation / physiology* Diastole Female Humans Hypertension / pathology, physiopathology*, radionuclide imaging Magnetic Resonance Imaging Male Middle Aged Sex Characteristics Systole Tomography, Emission-Computed, Single-Photon |
| Grant Support | |
ID/Acronym/Agency:
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2R01 AG015112/AG/NIA NIH HHS; 2R01 AG015112,/AG/NIA NIH HHS; K24 AG00930/AG/NIA NIH HHS; R01 AG015112-10/AG/NIA NIH HHS; R29 AG015112-05/AG/NIA NIH HHS; R29 AG15112/AG/NIA NIH HHS |
| Comments/Corrections | |
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