Document Detail


Reduced cerebral blood flow and N-acetyl aspartate in a murine model of cerebral malaria.
MedLine Citation:
PMID:  15918069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cerebral malaria is an important cause of morbidity and mortality in many parts of the world. It has been suggested that cerebral malaria is associated with reduced perfusion due to the blockage of blood vessels by parasitized erythrocytes; although, no quantitative validation of this has been done. We infected C57BL/6 mice with the ANKA strain of Plasmodium berghei and on day 6 of infection we investigated alterations in brain function using arterial spin labeling MRI and proton MRS. MR images did not demonstrate signs of damage. However, there was a significant reduction in cerebral blood flow (P<0.012) and the ratio of N-acetyl-aspartate (NAA) to creatine (Cr) (P<0.01) relative to non-infected mice. The NAA/Cr ratios were significantly correlated with cerebral perfusion (r=0.87) suggesting a relationship between impaired oxygen delivery and neuronal dysfunction. Pathological examination revealed accumulations of damaged axons providing a correlate for the decreased NAA/Cr ratio in infected mice. This murine model will permit non-invasive studies of neurologic function during malarial infection.
Authors:
Richard P Kennan; Fabiana S Machado; Sunhee C Lee; Mahalia S Desruisseaux; Murray Wittner; Moriya Tsuji; Herbert B Tanowitz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2005-05-26
Journal Detail:
Title:  Parasitology research     Volume:  96     ISSN:  0932-0113     ISO Abbreviation:  Parasitol. Res.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-01     Completed Date:  2005-09-28     Revised Date:  2014-06-06    
Medline Journal Info:
Nlm Unique ID:  8703571     Medline TA:  Parasitol Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  302-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Aspartic Acid / analogs & derivatives*,  metabolism
Axons / pathology
Brain / blood supply,  metabolism,  pathology,  radiography
Cerebrovascular Circulation*
Disease Models, Animal
Down-Regulation
Magnetic Resonance Imaging
Malaria, Cerebral / metabolism*,  pathology,  physiopathology*
Mice
Mice, Inbred C57BL
Plasmodium berghei*
Grant Support
ID/Acronym/Agency:
AI-12770/AI/NIAID NIH HHS; EB-R21-1787/EB/NIBIB NIH HHS; L32 MD002222/MD/NIMHD NIH HHS; P30 AI051519/AI/NIAID NIH HHS; T32 HL007675/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
30KYC7MIAI/Aspartic Acid; 997-55-7/N-acetylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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