Document Detail

Reduced cerebellar diameter in very preterm infants with abnormal general movements.
MedLine Citation:
PMID:  20004536     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Abnormal General Movements (GMs) early in life are predictive of later neuromotor deficits and are related to white matter abnormalities on magnetic resonance imaging (MRI). However, other structural correlates of abnormal GMs have not been defined. AIMS: The objective of this study was to explore brain-metrics (linear brain measurements on MRI representative of 3-D brain volumes) at term as a predictor of abnormal GMs at 1 and 3months' corrected age in preterm infants. It was hypothesized that abnormal GMs would be related to reduced brain-metrics in primary motor areas, namely the cerebellum and parietal lobes. STUDY DESIGN: Eighty three preterm infants (<30weeks' gestational age) were scanned at term-equivalent age. MRI was assessed for white matter abnormality and brain-metrics in six predefined brain regions (i.e. bifrontal, biparietal, lateral ventricles and transverse cerebellar diameters, and inter-hemispheric distance). OUTCOME MEASURES: At 1 and 3months' corrected age infants' GMs were assessed from video-taped footage and rated as normal or abnormal using standardized methodology. RESULTS: At 1month, 63% (n=52) of infants had abnormal GMs with no association between any of the brain-metrics and abnormal GMs. At 3months, 23% (n=18) of infants had abnormal GMs (absent fidgety movements n=18; abnormal fidgety movements n=0). Reduced bifrontal, biparietal, and cerebellar transverse diameters, along with an increase in lateral ventricle sizes were associated with an increased risk of abnormal GMs at 3months' corrected age. After controlling for white matter abnormality and grade III/IV intraventricular haemorrhage, only the cerebellar transverse diameter was predictive of abnormal GMs at 3months. CONCLUSIONS: Reduced cerebellar diameter at term equivalent age is related to abnormal GMs at 3months' corrected age, independent of white matter abnormality and intraventricular haemorrhage.
Alicia J Spittle; Lex W Doyle; Peter J Anderson; Terrie E Inder; Katherine J Lee; Roslyn N Boyd; Jeanie L Y Cheong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-09
Journal Detail:
Title:  Early human development     Volume:  86     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-17     Completed Date:  2010-05-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Murdoch Childrens Research Institute, Victoria, Australia. <>
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MeSH Terms
Age Factors
Cerebellum / pathology*
Dyskinesias / pathology*
Image Processing, Computer-Assisted
Infant, Newborn
Infant, Premature
Magnetic Resonance Imaging
Nerve Fibers, Myelinated / pathology
Odds Ratio
Organ Size

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