| Reduced carriership of 4G allele of plasminogen activator inhibitor-1 4G/5G polymorphism in very young survivors of myocardial infarction. | |
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MedLine Citation:
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PMID: 19844663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There are limited and controversial data regarding the impact of 4G/5G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene in the pathogenesis of premature myocardial infarction (MI). We explored whether 4G/5G polymorphism of the PAI-1 gene is associated with the development of MI <or= 35 years of age. We recruited 201 consecutive patients who had survived their first acute MI <or= 35 years of age (mean age = 32.2 +/- 3.4 years). The control group consisted of 140 healthy individuals matched with cases for age and sex, without a family history of premature coronary heart disease. 4G/5G polymorphism of PAI-1 was tested with polymerase chain reaction and reverse hybridization. 4G allele carriers (4G/4G and 4G/5G genotypes) of PAI-1 were less frequent in patients than in controls (69.6 vs. 83.6%, P = 0.007). 4G carriership of the polymorphism of PAI-1 was associated with lower risk for acute MI (odds ratio 0.45, 95% confidence interval 0.23-0.88, P = 0.02) after adjusting for major cardiovascular risk factors. Patients possessing the 4G allele had higher PAI-1 plasma levels (32.2 +/- 25 vs. 22.2 +/- 11.3 ng/ml, P = 0.006) but lower lipoprotein(a) levels (10.1 [2.1-29.9] vs. 15.3 [8.2-57.1] mg/dl, P = 0.03) compared to 5G/5G homozygotes. Our data indicate that the 4G allele of the PAI-1 4G/5G polymorphism is less frequent among survivors of MI at very young age compared with matched controls. |
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Authors:
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Loukianos S Rallidis; Argyri Gialeraki; Efrosyni Merkouri; George Liakos; Nikolaos Dagres; Dimitrios Sionis; Anthi Travlou; John Lekakis; Dimitrios T Kremastinos |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study |
Journal Detail:
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Title: Journal of thrombosis and thrombolysis Volume: 29 ISSN: 1573-742X ISO Abbreviation: J. Thromb. Thrombolysis Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-10 Completed Date: 2010-08-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9502018 Medline TA: J Thromb Thrombolysis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 497-502 Citation Subset: IM |
Affiliation:
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Second Department of Cardiology, Attikon Hospital, School of Medicine, University of Athens, Athens, Greece. rallidis@ath.forthnet.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alleles* Female Homozygote Humans Lipoprotein(a) / blood Male Myocardial Infarction / blood, genetics*, mortality Plasminogen Activator Inhibitor 1 / blood, genetics* Polymorphism, Genetic* Retrospective Studies Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Lipoprotein(a); 0/Plasminogen Activator Inhibitor 1; 0/SERPINE1 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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