| Reduced cardio-respiratory coupling in acute alcohol withdrawal. | |
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MedLine Citation:
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PMID: 18621487 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Chronic alcoholism represents a risk factor for cardiac arrhythmias. One underlying mechanism is a sympathetically dominated autonomic imbalance. This is especially apparent during acute withdrawal from alcohol. Since linear analysis of heart rate variability may not be entirely adequate to detect such autonomic dysfunction in acute alcohol withdrawal, we applied novel non-linear parameters and measures for cardio-respiratory coupling. METHODS: 20 patients suffering from acute alcohol withdrawal syndrome and 20 controls were included. For patients, heart rate and respiration were recorded on admission, after medication and at discharge. From these data, complexity measures (symbolic dynamics, approximate entropy) of heart rate modulation and respiration as well as parameters for cardio-respiratory coupling (coherence, cross-approximate entropy) which relate to vagal function were calculated. RESULTS: Heart rate modulation was significantly less complex in patients acutely admitted for alcohol withdrawal. Furthermore, coupling between beat-to-beat (RR) intervals and respiration time series was significantly diminished. Of the parameters assessed, cross-approximate entropy showed a trend for correlation with symptom severity. CONCLUSION: These data indicate diminished vagal function in acute alcohol withdrawal. Applying the methods described thus allows a sensitive detection of vagal neuropathy in this disease. |
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Authors:
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Karl-Jürgen Bär; Michael Karl Boettger; Steffen Schulz; Rene Neubauer; Thomas Jochum; Andreas Voss; Vikram K Yeragani |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-14 |
Journal Detail:
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Title: Drug and alcohol dependence Volume: 98 ISSN: 0376-8716 ISO Abbreviation: Drug Alcohol Depend Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-10-20 Completed Date: 2009-01-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7513587 Medline TA: Drug Alcohol Depend Country: Ireland |
Other Details:
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Languages: eng Pagination: 210-7 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Friedrich-Schiller-University, Philosophenweg 3, Jena, Germany. Karl-Juergen.Baer@med.uni-jena.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alcoholism / psychology Algorithms Cardiovascular Physiological Phenomena / drug effects* Central Nervous System Depressants / adverse effects* Chlormethiazole / therapeutic use Entropy Ethanol / adverse effects* Heart Rate / drug effects Humans Hypnotics and Sedatives / therapeutic use Male Multivariate Analysis Psychiatric Status Rating Scales Respiratory Mechanics / drug effects* Substance Withdrawal Syndrome / drug therapy, physiopathology* Vagus Nerve / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Depressants; 0/Hypnotics and Sedatives; 533-45-9/Chlormethiazole; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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