Document Detail

Reduced cardio-respiratory coupling in acute alcohol withdrawal.
MedLine Citation:
PMID:  18621487     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Chronic alcoholism represents a risk factor for cardiac arrhythmias. One underlying mechanism is a sympathetically dominated autonomic imbalance. This is especially apparent during acute withdrawal from alcohol. Since linear analysis of heart rate variability may not be entirely adequate to detect such autonomic dysfunction in acute alcohol withdrawal, we applied novel non-linear parameters and measures for cardio-respiratory coupling. METHODS: 20 patients suffering from acute alcohol withdrawal syndrome and 20 controls were included. For patients, heart rate and respiration were recorded on admission, after medication and at discharge. From these data, complexity measures (symbolic dynamics, approximate entropy) of heart rate modulation and respiration as well as parameters for cardio-respiratory coupling (coherence, cross-approximate entropy) which relate to vagal function were calculated. RESULTS: Heart rate modulation was significantly less complex in patients acutely admitted for alcohol withdrawal. Furthermore, coupling between beat-to-beat (RR) intervals and respiration time series was significantly diminished. Of the parameters assessed, cross-approximate entropy showed a trend for correlation with symptom severity. CONCLUSION: These data indicate diminished vagal function in acute alcohol withdrawal. Applying the methods described thus allows a sensitive detection of vagal neuropathy in this disease.
Karl-Jürgen Bär; Michael Karl Boettger; Steffen Schulz; Rene Neubauer; Thomas Jochum; Andreas Voss; Vikram K Yeragani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-14
Journal Detail:
Title:  Drug and alcohol dependence     Volume:  98     ISSN:  0376-8716     ISO Abbreviation:  Drug Alcohol Depend     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-10-20     Completed Date:  2009-01-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513587     Medline TA:  Drug Alcohol Depend     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  210-7     Citation Subset:  IM    
Department of Psychiatry, Friedrich-Schiller-University, Philosophenweg 3, Jena, Germany.
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MeSH Terms
Alcoholism / psychology
Cardiovascular Physiological Phenomena / drug effects*
Central Nervous System Depressants / adverse effects*
Chlormethiazole / therapeutic use
Ethanol / adverse effects*
Heart Rate / drug effects
Hypnotics and Sedatives / therapeutic use
Multivariate Analysis
Psychiatric Status Rating Scales
Respiratory Mechanics / drug effects*
Substance Withdrawal Syndrome / drug therapy,  physiopathology*
Vagus Nerve / physiopathology
Reg. No./Substance:
0/Central Nervous System Depressants; 0/Hypnotics and Sedatives; 533-45-9/Chlormethiazole; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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