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Reduced cardiac remodelling and prevention of glutathione deficiency after omega-3 supplementation in chronic heart failure.
MedLine Citation:
PMID:  20584202     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
n-3 polyunsaturated fatty acids (omega-3) supplementation is associated with reduced cardiovascular mortality and post-infarction death. However, the impact of omega-3 supplementation in congestive heart failure (CHF) is still unknown. This study assesses the effects of omega-3 supplementation on left ventricular (LV) function and remodelling. We assessed, in rats with CHF induced by left coronary ligation, the effects of a 1-week and a 12-week supplementation with omega-3 (450 mg/kg per day) on LV hemodynamics, function and structure. Chronic omega-3 reduces total peripheral resistance due to an increase in cardiac output without modification of arterial pressure. Only chronic omega-3 reduces LV end-diastolic pressure and LV relaxation constant. Moreover, chronic omega-3 decreases LV systolic and diastolic diameters, LV weight and collagen density. Acute and chronic omega-3 increase LV γ-glutamyl-cysteine synthetase and oppose glutathione deficiency resulting in a reduction of myocardial oxidized glutathione. In experimental CHF, long-term omega-3 supplementation improves LV hemodynamics and function and prevents LV remodelling and glutathione deficiency. The latter might be one of the mechanisms involved, but whether other mechanism, independent of myocardial redox 'status', such as reduced inflammation, are implicated remains to be confirmed.
Authors:
Yuehua Fang; Julie Favre; Magalie Vercauteren; Brigitte Laillet; Isabelle Remy-Jouet; Mohamed Skiba; Françoise Lallemand; Cathy Dehaudt; Christelle Monteil; Christian Thuillez; Paul Mulder
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fundamental & clinical pharmacology     Volume:  25     ISSN:  1472-8206     ISO Abbreviation:  Fundam Clin Pharmacol     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-04-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710411     Medline TA:  Fundam Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  323-32     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors Fundamental and Clinical Pharmacology © 2010 Société Française de Pharmacologie et de Thérapeutique.
Affiliation:
INSERM U644, Institut Fédératif de Recherches Multidisciplinaires sur les Peptides n°23, Rouen Institut for Biomedical Research and Inovation, UFR de Médecine et de Pharmacie, 22 Boulevard Gambetta, 76183 Rouen, France.
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