Document Detail

Reduced cardiac mass by nitrendipine is dissociated from systemic or regional haemodynamic changes in rats.
MedLine Citation:
PMID:  6705007     Owner:  NLM     Status:  MEDLINE    
The effects of prolonged treatment (3 weeks) with nitrendipine (10 mg X kg-1 twice daily) on systemic and regional haemodynamics and cardiac mass were studied in SHR and WKY rats. Nitrendipine markedly decreased mean arterial pressure (26.0 +/- 0.4 vs 19.9 +/- 0.6 kPa, P less than 0.01) and total peripheral resistance (0.090 +/- 0.004 vs 0.066 +/- 0.004 U X kg-1, P less than 0.01) in SHR without significantly affecting cardiac output and heart rate, whereas in the WKY rats no significant systemic haemodynamic changes were noted. Increased splanchnic blood flow and a reduced splanchnic vascular resistance were found in the WKY rats; however, in the SHR rats, blood flows (ml X min-1 X g tissue-1) increased and organ vascular resistances (kPa X ml-1 X min-1 X 100 g tissue-1) decreased significantly (P less than 0.01) in the heart (5.25 +/- 0.28 vs 7.27 +/- 0.31 and 0.04 +/- 0.00 vs 0.02 +/- 0.00; P less than 0.01) and kidneys (6.53 +/- 0.4 vs 7.98 +/- 0.2 and 0.03 +/- 0.00 vs 0.02 +/- 0.00; P less than 0.01), respectively. Nevertheless, in both rat strains, absolute cardiac mass and left ventricular weight were reduced; but in the SHR rats, the relative weight of the heart and left ventricle to body weight was also reduced significantly (3.79 +/- 0.06 vs 3.31 +/- 0.09; P less than 0.01 and 2.85 +/- 0.06 vs 2.70 +/- 0.06; P less than 0.01, respectively). Thus, these studies show that nitrendipine, a slow-entry channel calcium blocker, regressed cardiac mass in rats through mechanisms that may be dissociated from their haemodynamic changes.
I Kobrin; S Sesoko; B L Pegram; E D Frohlich
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular research     Volume:  18     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-05-14     Completed Date:  1984-05-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  158-62     Citation Subset:  IM    
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MeSH Terms
Blood Flow Velocity
Blood Pressure / drug effects
Body Weight / drug effects
Calcium Channel Blockers / pharmacology*
Heart / anatomy & histology,  drug effects*
Hemodynamics / drug effects*
Nifedipine / analogs & derivatives*,  pharmacology
Organ Size / drug effects
Rats, Inbred Strains
Vascular Resistance / drug effects
Reg. No./Substance:
0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 39562-70-4/Nitrendipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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