Document Detail


Reduced capability of transmitting high frequency impulses in tail nerves of diabetic rats.
MedLine Citation:
PMID:  8446126     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of long-term (40 min) high frequency stimulation (143 Hz) of sensory-motor tail nerves was studied in normal and in streptozotocin-diabetic rats. The study comprised a 6-week period, repeating the test at 2-week intervals. In the initial (prediabetic) study, single experiments showed a mild depression of the peak-to-peak amplitude during high frequency stimulation, which reversed completely during a subsequent rest period. In normal rats, the amplitude depression was unchanged in repeated tests over a 6-week period. Diabetic rats showed a greater amplitude depression during high frequency stimulation. The difference was statistically significant after 2 weeks, but showed no further change at subsequent tests. The greater decrease in the amplitude in diabetic rats may reflect a depression of the axon membrane function, which may be the functional correlate to the inhibition of the Na/K ATPase activity in diabetes, described by others. Monitoring of the axon membrane functional capacity may have clinical implications in the control of peripheral neuropathies.
Authors:
J F Nielsen; H Andersen; V K Nielsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Muscle & nerve     Volume:  16     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-04-06     Completed Date:  1993-04-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  283-8     Citation Subset:  IM    
Affiliation:
Department of Neurophysiology, Arhus University Hospital, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials
Animals
Diabetes Mellitus, Experimental / chemically induced,  physiopathology*
Electric Stimulation
Longitudinal Studies
Male
Neural Conduction / physiology*
Rats
Rats, Wistar
Streptozocin
Tail / innervation,  physiopathology*
Chemical
Reg. No./Substance:
18883-66-4/Streptozocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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