| Reduced calcium responsiveness characterizes contractile dysfunction following coronary microembolization. | |
| | |
MedLine Citation:
|
PMID: 18575914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: We addressed calcium responsiveness in microembolized myocardium at 6 h after coronary microembolization (ME). METHODS AND RESULTS: In anesthetized pigs calcium responsiveness was determined as the increase of a myocardial work index (WI; LV pressure development vs. wall thickening) in response to a graded intracoronary infusion of CaCl(2) at baseline and at 6 h after ME or placebo, respectively. At baseline, CaCl(2 )infusion increased WI in both groups (ME: 296 +/- 22 to 468 +/- 47 mmHg*mm; placebo: 324 +/- 24 to 485 +/- 38 mmHg*mm; mean +/- SEM). At 6 h after ME, WI was decreased by 159 +/- 16 mmHg*mm (P < 0.05 vs. baseline) and remained reduced at any calcium concentration, whereas it was unchanged with placebo. The calcium concentration in coronary blood necessary to achieve the half maximal increase in WI remained unchanged from baseline to 6 h and did not differ between placebo and ME. CONCLUSION: The ME-induced myocardial dysfunction is not related to an altered calcium sensitivity, but is characterized by a reduced maximal contractile force. |
| | |
Authors:
|
Andreas Skyschally; Petra Gres; Patrick van Caster; Anita van de Sand; Kerstin Boengler; Rainer Schulz; Gerd Heusch |
Related Documents
:
|
592474 - Cyclical reduction in blood flow of partially constricted coronary artery in dogs. ii. ... 4015734 - Pharmacological studies of a newly synthetized 1,4-dihydropyridine derivative, 2,6-dime... 12796134 - Functional changes in coronary microcirculation after valve replacement in patients wit... 6956474 - Verapamil: a selective antagonist of constrictor substances in dog coronary artery: imp... 6145114 - Hypertensive response following stimulation of opiate receptors in the caudal ventrolat... 16380524 - Weather-related changes in 24-hour blood pressure profile: effects of age and implicati... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-06-23 |
Journal Detail:
|
Title: Basic research in cardiology Volume: 103 ISSN: 1435-1803 ISO Abbreviation: Basic Res. Cardiol. Publication Date: 2008 Nov |
Date Detail:
|
Created Date: 2008-10-10 Completed Date: 2009-02-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0360342 Medline TA: Basic Res Cardiol Country: Germany |
Other Details:
|
Languages: eng Pagination: 552-9 Citation Subset: IM |
Affiliation:
|
Institute of Pathophysiology, University School of Medicine, Essen, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / drug effects, physiology Calcium / metabolism, pharmacology* Coronary Occlusion / physiopathology* Coronary Vessels / drug effects, physiology Disease Models, Animal Dose-Response Relationship, Drug Embolism / physiopathology* Female Heart Rate / drug effects, physiology Male Myocardial Contraction / drug effects*, physiology Myocardium / metabolism Regional Blood Flow / drug effects, physiology Swine Swine, Miniature Time Factors Tropomyosin / metabolism Tumor Necrosis Factor-alpha / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Tropomyosin; 0/Tumor Necrosis Factor-alpha; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A process and criteria for the evaluation of software frameworks in the domain of computer assisted ...
Next Document: The generalized anxiety spectrum: prevalence, onset, course and outcome.