| Reduced blood pressure lability during emergence from anaesthesia in rats: a pilot study using clonidine. | |
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MedLine Citation:
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PMID: 17995999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In the post-operative setting, pressure lability is increased in hypertensive patients. alpha-2 agonists were shown qualitatively to reduce this lability qualitatively. Here, upon immobilization combined with emergence from anesthesia in rats and clonidine administration, pressure lability was quantitatively assessed and related to baroreflex sensitivity. METHODS: After local anesthesia of all incisions and surgical wounds and myorelaxation with metocurine, rats had halothane withdrawn for 60 min. Rats received (a) saline (n=8), (b) clonidine 30 microg/kg i.v (n=8) simultaneous to halothane discontinuation and (c) halothane readministration (n=8) 20 min after halothane discontinuation. Pressure lability was quantitatively assessed using occurrence/amplitude of peaks in systolic blood pressure (SBP) and cardiac baroreflex slope. RESULTS: Clonidine was associated with partial blunting of hypertension, reduced standard deviation of SBP, reduced number and amplitude of peaks in systolic pressure. Clonidine was also associated with increased slope of the cardiac baroreflex upon early intervals of emergence, but not at later intervals. CONCLUSION: Clonidine reduces pressure lability upon immobilization stress combined to emergence from anesthesia, via parasympathetic activation and possibly sympathetic inhibition during early emergence as opposed to sympathetic inhibition during late emergence. |
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Authors:
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A Cividjian; N Rentero; L Quintin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-11-08 |
Journal Detail:
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Title: Acta anaesthesiologica Scandinavica Volume: 52 ISSN: 1399-6576 ISO Abbreviation: Acta Anaesthesiol Scand Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-18 Completed Date: 2008-03-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370270 Medline TA: Acta Anaesthesiol Scand Country: England |
Other Details:
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Languages: eng Pagination: 295-301 Citation Subset: IM |
Affiliation:
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Physiology, CNRS 5123-University of Lyon, Lyon, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics
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pharmacology* Analysis of Variance Anesthesia / methods* Anesthesia Recovery Period Anesthetics, Inhalation / administration & dosage Animals Blood Pressure / drug effects* Clonidine / pharmacology* Halothane / administration & dosage Hypertension / prevention & control Male Pilot Projects Rats Rats, Sprague-Dawley Sodium Chloride / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Anesthetics, Inhalation; 151-67-7/Halothane; 4205-90-7/Clonidine; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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