Document Detail


Reduced blood levels of coagulation inhibitors in chronic hemodialysis compared with CAPD.
MedLine Citation:
PMID:  8534685     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to measure the coagulation inhibitors in two groups of uremic patients treated with hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) to evaluate the differences in anticoagulant activity. In 20 patients on HD and 20 on CAPD, mean age 66 +/- 8 and 58 +/- 14 years, respectively, the following parameters were determined between dialysis exchanges: protein C (PC), protein S (PS), antithrombin III (AT III), electrophoresis, prothrombin activation fragment (F1+2), alpha 1 antitripsin (alpha 1 AT), prothrombin time (PT), and activated partial thromboplastin time (PTT). The mean values of PC, PS, and AT III were respectively, 95.7 +/- 16 on HD and 92 +/- 23 on CAPD; 82.2 +/- 13.6 on HD and 90.5 +/- 13.6 on CAPD; the mean value F1+2 was 1.2 +/- 0.5 on HD and 1.04 +/- 0.5 on CAPD (p < 0.05). A good correlation between PS and AT III% functional activity (p < 0.03, r = 0.5) in both groups was found. More-over, PS functional activity was inversely correlated with duration of dialysis (p < 0.05, r = -0.3). HD patients showed a reduction of coagulation inhibitors compared with CAPD patients. Such a phenomenon could justify the increased thrombotic risk in HD patients. Since 80% of those on HD and only 20% of those on CAPD received erythropoietin (EPO), the prothrombotic state in HD could be due to reduced PS activity secondary to EPO treatment.
Authors:
S V Bertoli; G B di Belgiojoso; M Trezzi; D Scorza; M T Barone; M Poggio; E Rossi; N Landriani; A Genderini
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Advances in peritoneal dialysis. Conference on Peritoneal Dialysis     Volume:  11     ISSN:  1197-8554     ISO Abbreviation:  Adv Perit Dial     Publication Date:  1995  
Date Detail:
Created Date:  1996-02-02     Completed Date:  1996-02-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9104803     Medline TA:  Adv Perit Dial     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  127-30     Citation Subset:  IM    
Affiliation:
Nephrology Department, Sacco Hospital, Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Aged
Anticoagulants
Antithrombin III / analysis
Blood Coagulation*
Female
Humans
Male
Middle Aged
Peptide Fragments / analysis
Peritoneal Dialysis, Continuous Ambulatory*
Protein C / analysis
Protein S / analysis
Prothrombin / analysis
Prothrombin Time
Renal Dialysis*
Serum Albumin / analysis
Uremia / blood,  therapy
alpha 1-Antitrypsin / analysis
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Peptide Fragments; 0/Protein C; 0/Protein S; 0/Serum Albumin; 0/alpha 1-Antitrypsin; 0/prothrombin fragment 1.2; 9000-94-6/Antithrombin III; 9001-26-7/Prothrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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