| Reduced blood levels of coagulation inhibitors in chronic hemodialysis compared with CAPD. | |
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MedLine Citation:
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PMID: 8534685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to measure the coagulation inhibitors in two groups of uremic patients treated with hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) to evaluate the differences in anticoagulant activity. In 20 patients on HD and 20 on CAPD, mean age 66 +/- 8 and 58 +/- 14 years, respectively, the following parameters were determined between dialysis exchanges: protein C (PC), protein S (PS), antithrombin III (AT III), electrophoresis, prothrombin activation fragment (F1+2), alpha 1 antitripsin (alpha 1 AT), prothrombin time (PT), and activated partial thromboplastin time (PTT). The mean values of PC, PS, and AT III were respectively, 95.7 +/- 16 on HD and 92 +/- 23 on CAPD; 82.2 +/- 13.6 on HD and 90.5 +/- 13.6 on CAPD; the mean value F1+2 was 1.2 +/- 0.5 on HD and 1.04 +/- 0.5 on CAPD (p < 0.05). A good correlation between PS and AT III% functional activity (p < 0.03, r = 0.5) in both groups was found. More-over, PS functional activity was inversely correlated with duration of dialysis (p < 0.05, r = -0.3). HD patients showed a reduction of coagulation inhibitors compared with CAPD patients. Such a phenomenon could justify the increased thrombotic risk in HD patients. Since 80% of those on HD and only 20% of those on CAPD received erythropoietin (EPO), the prothrombotic state in HD could be due to reduced PS activity secondary to EPO treatment. |
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Authors:
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S V Bertoli; G B di Belgiojoso; M Trezzi; D Scorza; M T Barone; M Poggio; E Rossi; N Landriani; A Genderini |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Advances in peritoneal dialysis. Conference on Peritoneal Dialysis Volume: 11 ISSN: 1197-8554 ISO Abbreviation: Adv Perit Dial Publication Date: 1995 |
Date Detail:
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Created Date: 1996-02-02 Completed Date: 1996-02-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9104803 Medline TA: Adv Perit Dial Country: CANADA |
Other Details:
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Languages: eng Pagination: 127-30 Citation Subset: IM |
Affiliation:
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Nephrology Department, Sacco Hospital, Milan, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anticoagulants Antithrombin III / analysis Blood Coagulation* Female Humans Male Middle Aged Peptide Fragments / analysis Peritoneal Dialysis, Continuous Ambulatory* Protein C / analysis Protein S / analysis Prothrombin / analysis Prothrombin Time Renal Dialysis* Serum Albumin / analysis Uremia / blood, therapy alpha 1-Antitrypsin / analysis |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Peptide Fragments; 0/Protein C; 0/Protein S; 0/Serum Albumin; 0/alpha 1-Antitrypsin; 0/prothrombin fragment 1.2; 9000-94-6/Antithrombin III; 9001-26-7/Prothrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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