| Reduced benefit from mnemonic strategies in early-stage Alzheimer's disease: a brief testing-the-limits paradigm for clinical practice. | |
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MedLine Citation:
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PMID: 20535494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Discriminating incipient Alzheimer's disease (AD) from major depression (MD) and age related memory decline is a challenge in clinical practice. Since AD is characterized by an early loss of neuronal and functional plasticity, a dynamic test strategy, such as the testing-the-limits (TtL) approach, that measures learning capacity can be a helpful diagnostic tool. To evaluate this, a short recognition paradigm consisting of a pre-test (baseline) and two post-test conditions with an interposed encoding instruction was developed and administered to individuals with incipient AD (n = 19; Mini Mental Status Examination (MMSE) 26.5), patients with depressive disorders (n = 11; MMSE 30), and healthy controls (n = 11; MMSE 30). In addition, participants completed a set of traditional neuropsychological tests that focused on the subjects' cognitive baseline performance. Intergroup comparisons (Kruskal-Wallis, U test) revealed significantly higher post-test failure rates in AD patients. Pre-test performance of MD and AD patients did not differ. Intra-group comparisons (Friedman, Wilcoxon test) showed that all three subject samples benefit from intervention in post-test 1. In contrast to MD and healthy individuals, who revealed significantly lower failure rates in post-test 2 compared to the pre-test, AD patients did not improve. Out of the 15 traditional test scores obtained, only two discriminated simultaneously between AD and each of the other groups. Our data confirm the finding of an impaired cognitive plasticity already present in very early stages of AD and illustrate the efficiency of a dynamic test approach in identifying incipient dementia. |
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Authors:
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Ingo Uttner; Niklas Schurig; Christine A F von Arnim; Christian Lange-Asschenfeldt; Hayrettin Tumani; Matthias W Riepe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-11 |
Journal Detail:
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Title: Journal of neurology Volume: 257 ISSN: 1432-1459 ISO Abbreviation: J. Neurol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-08 Completed Date: 2011-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0423161 Medline TA: J Neurol Country: Germany |
Other Details:
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Languages: eng Pagination: 1718-26 Citation Subset: IM |
Affiliation:
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Neurologische Klinik der Universität Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany. ingo.uttner@uni-ulm.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / complications*, diagnosis* Attention / physiology Cognition Disorders / diagnosis*, etiology* Depressive Disorder, Major / diagnosis Female Humans Male Mental Status Schedule Middle Aged Neuropsychological Tests Psychometrics Recognition (Psychology) Statistics, Nonparametric |
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