Document Detail

Reduced basal GABA concentrations in the rat amygdala during pregnancy.
MedLine Citation:
PMID:  16519910     Owner:  NLM     Status:  MEDLINE    
Marked increases in anxiety-like responses to stress occur during pregnancy. Considerable evidence indicates that the basolateral region of the amygdala (BLA) plays an important role in mediating these types of responses. Given the crucial inhibitory influence of GABA on excitatory glutamatergic activity in the BLA, we hypothesized that decreased GABAergic activity in this region may underlie the increased anxiety associated with pregnancy. In vivo microdialysis was used to sample extracellular GABA before and after 30 min of restraint stress. While there was no detectable effect of restraint on extracellular GABA concentrations, basal GABA levels were significantly decreased in pregnant rats compared with either virgin females or males. We suggest that the alterations in anxiety-like behavior that occur during pregnancy may be associated with decreased basal GABA in the BLA.
Brian J Young; Christian J Cook
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-07
Journal Detail:
Title:  Physiology & behavior     Volume:  87     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-06     Completed Date:  2006-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  817-20     Citation Subset:  IM    
Ministry of Research, Science & Technology, Level 10, 2 The Terrace, PO Box 5336, Wellington, New Zealand.
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MeSH Terms
Amygdala / metabolism*
Anxiety / etiology,  metabolism*
Pregnancy / metabolism*,  psychology
Rats, Sprague-Dawley
Restraint, Physical
Stress, Psychological / complications,  metabolism*
gamma-Aminobutyric Acid / metabolism*
Reg. No./Substance:
56-12-2/gamma-Aminobutyric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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