Document Detail

Reduced baroreflex sensitivity in acute alcohol withdrawal syndrome and in abstained alcoholics.
MedLine Citation:
PMID:  16650658     Owner:  NLM     Status:  MEDLINE    
Acute alcohol withdrawal is often associated with increased sympathetic activity, and a decreased baroreflex sensitivity (BRS) can be assumed. Parameters of heart rate variability (HRV), blood pressure variability (BPV), BRS as well as cardiac index (CI), left ventricular work index (LVWI) and total peripheral resistance (TPR) were investigated in 20 patients undergoing acute alcohol withdrawal and matched controls. Measures were obtained during the peak of withdrawal symptomatology prior to treatment as well as 2 and 24h under continuous clomethiazole treatment. Alcohol withdrawal scores were obtained and correlated with autonomic measures. In addition, parameters were assessed in 15 subjects who abstained from alcohol after long-term intake. We found a severe down-regulation of BRS during acute alcohol withdrawal and to a milder extent in abstained alcoholics. Furthermore, HRV and BPV did not unequivocally reveal signs of elevated sympathetic activity. Non-linear parameters of HRV and parameters of BRS correlated with the severity of AWS. The distinct decrease of BRS in AWS and in long-term abstained subjects described here is of importance since similar alterations have been identified as independent prognostic factors for cardiac mortality in other diseases.
Karl-Jürgen Bär; Michael Karl Boettger; Silke Boettger; Marei Grotelüschen; Rene Neubauer; Thomas Jochum; Vico Baier; Heinrich Sauer; Andreas Voss
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Publication Detail:
Type:  Journal Article     Date:  2006-05-02
Journal Detail:
Title:  Drug and alcohol dependence     Volume:  85     ISSN:  0376-8716     ISO Abbreviation:  Drug Alcohol Depend     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-08     Completed Date:  2007-02-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513587     Medline TA:  Drug Alcohol Depend     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  66-74     Citation Subset:  IM    
Department of Psychiatry, Friedrich-Schiller-University, Philosophenweg 3, 07743 Jena, Germany.
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MeSH Terms
Acute Disease
Alcoholism / rehabilitation*
Baroreflex / physiology*
Chlormethiazole / diagnostic use,  pharmacokinetics
Ethanol / adverse effects*
GABA Modulators / diagnostic use,  pharmacokinetics
Heart Rate / physiology
Hypertension / diagnosis,  epidemiology
Metabolic Detoxication, Drug*
Reflex, Abnormal / physiology*
Substance Withdrawal Syndrome / diagnosis,  etiology*,  physiopathology*
Reg. No./Substance:
0/GABA Modulators; 533-45-9/Chlormethiazole; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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