Document Detail

Reduced baroreceptor reflex sensitivity and increased blood pressure variability at 2400 m simulated cabin altitude.
MedLine Citation:
PMID:  12137097     Owner:  NLM     Status:  MEDLINE    
In a hypobaric chamber nine healthy volunteers were exposed to an atmospheric pressure corresponding to 2400 m above sea level. This is similar to the lowest air pressure encountered inside pressurized commercial airplanes. Heart rate and blood pressure were monitored beat-to-beat in the supine position with a non-invasive device. Blood pressure variability and heart rate variability were measured in the mid-frequency band; subsequently, baroreceptor reflex sensitivity (BRS) was calculated with the transfer-function method. Compared with baseline, there were reduced BRS and increased blood pressure variability at 2400 m (16.5 +/- 3.1 vs. 13.2 +/- 2.0 ms x mm Hg(-1) and 5.4 +/- 1.3 vs. 8.2 +/- 1.1 mm Hg, respectively; p < 0.05). We conclude that autonomic cardiovascular control was disturbed during acute exposure to an air pressure corresponding to 2400 m.
Knut Sevre; Bjørn Bendz; Morten Rostrup
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  73     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-24     Completed Date:  2003-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  632-4     Citation Subset:  IM; S    
Department of Cardiology, Ullevål University Hospital, Oslo, Norway.
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MeSH Terms
Aerospace Medicine*
Analysis of Variance
Autonomic Nervous System / physiology
Baroreflex / physiology*
Blood Pressure / physiology*
Heart Rate / physiology
Homeostasis / physiology
Monitoring, Physiologic
Pressoreceptors / physiology*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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