Document Detail


Reduced ascending aorta distensibility relates to adverse ventricular mechanics in patients with hypoplastic left heart syndrome: noninvasive study using wave intensity analysis.
MedLine Citation:
PMID:  23031685     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the aortic arch elastic properties and ventriculoarterial coupling efficiency in patients with single ventricle physiology, with and without a surgically reconstructed arch.
METHODS: We studied 21 children with single ventricle physiology after bidirectional superior cavopulmonary surgery: 10 with hypoplastic left heart syndrome, who underwent surgical arch reconstruction, and 11 with other types of single ventricle physiology but without arch reconstruction. All children underwent pre-Fontan magnetic resonance imaging. No patient exhibited aortic recoarctation. Data on aortic wave speed, aortic distensibility and wave intensity profiles were all extracted from the magnetic resonance imaging studies using an in-house-written plug-in for the Digital Imaging and Communications in Medicine viewer OsiriX.
RESULTS: Children with hypoplastic left heart syndrome had significantly greater wave speed (P = .002), and both stiffer (P = .004) and larger (P < .0001) ascending aortas than the patients with a nonreconstructed arch. Aortic distensibility was not influenced by ventricular stroke volume but depended on a combination of increased aortic diameter and abnormal wall mechanical properties. Those with hypoplastic left heart syndrome had a lower peak wave intensity and reduced energy carried by the forward compression and the forward expansion waves, even after correction for stroke volume, suggesting an abnormal systolic and diastolic function. Lower wave energy was associated with an increased aortic diameter.
CONCLUSIONS: Using a novel, noninvasive technique based on image analysis, we have demonstrated that aortic arch reconstruction in children with hypoplastic left heart syndrome is associated with reduced aortic distensibility and unfavorable ventricular-vascular coupling compared with those with single ventricle physiology without aortic arch reconstruction.
Authors:
Giovanni Biglino; Silvia Schievano; Jennifer A Steeden; Hopewell Ntsinjana; Catriona Baker; Sachin Khambadkone; Marc R de Leval; Tain-Yen Hsia; Andrew M Taylor; Alessandro Giardini;
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Publication Detail:
Type:  Journal Article     Date:  2012-09-29
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  144     ISSN:  1097-685X     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-12     Completed Date:  2013-01-22     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1307-13; discussion 1313-4     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aorta, Thoracic / physiopathology*,  surgery
Arterial Pressure
Cardiac Output
Child
Child, Preschool
Elasticity
Female
Fontan Procedure
Humans
Hypoplastic Left Heart Syndrome / diagnosis,  physiopathology*,  surgery
Linear Models
Magnetic Resonance Imaging
Male
Models, Cardiovascular
Pulse Wave Analysis*
Stroke Volume
Vascular Stiffness*
Ventricular Function*
Grant Support
ID/Acronym/Agency:
FS/12/35/29566//British Heart Foundation
Investigator
Investigator/Affiliation:
Edward Bove / ; Adam Dorfman / ; Andrew Taylor / ; Alessandro Giardini / ; Sachin Khambadkone / ; Marc de Leval / ; Silvia Schievano / ; T-Y Hsia / ; G Hamilton Baker / ; Anthony Hlavacek / ; Francesco Migliavacca / ; Giancarlo Pennati / ; Gabriele Dubini / ; Richard Figliola / ; John McGregor / ; Alison Marsden / ; Jeff Feinstein / ; Irene Vignon-Clementel /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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