Document Detail


Reduced aortic elastic properties in a child with Takayasu arteritis: case report and literature review.
MedLine Citation:
PMID:  16044277     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Takayasu arteritis (TA) is a chronic inflammatory vasculitis of the aorta and its major branches with a very low incidence in Europe and North America. Our objective was to determine the elastic properties of the affected ascending and descending aortic walls non-invasively in a 14-year-old Iraqi girl with a 3-year history of fever, fatigue, malaise and diffuse pain. Ultrasound and magnetic resonance angiography showed marked thickening of the aortic wall, dilatation of the aortic arch, and decreased luminal diameters of the abdominal aorta and both subclavian arteries, consistent with TA. Ascending and descending aortic elastic properties such as distensibility and stiffness index were markedly reduced compared to a group of healthy controls (n=39): ascending aortic distensibility was 20 kPa(-1) x 10(-3) versus 63+/-23 kPa(-1) x 10(-3) in controls, and the ascending aortic stiffness index 9.6 versus 3.5+/-1.3 in controls. Although the patient's general condition improved rapidly on oral prednisolone and azathioprine and inflammatory parameters normalised within 3 weeks, the aortic elastic parameters did not change during the first 2 weeks of anti-inflammatory treatment. Unfortunately, no further follow-up was possible. CONCLUSION: In patients with Takayasu arteritis, non-invasive quantification of reduced aortic elastic properties can help to assess aortic involvement, and possibly to follow disease activity and vascular response to therapy.
Authors:
Daniela Baumgartner; Michaela Sailer-Höck; Christian Baumgartner; Thomas Trieb; Heiner Maurer; Michael Schirmer; Lothar-Bernd Zimmerhackl; Jörg-Ingolf Stein
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2005-07-26
Journal Detail:
Title:  European journal of pediatrics     Volume:  164     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-19     Completed Date:  2006-07-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  685-90     Citation Subset:  IM    
Affiliation:
Division of Paediatric Cardiology, Department of Paediatrics, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria. daniela.baumgartner@aon.at
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MeSH Terms
Descriptor/Qualifier:
Abdominal Pain / etiology
Adolescent
Aorta / drug effects,  pathology*,  physiopathology
Azathioprine / therapeutic use
Female
Fever / etiology
Glucocorticoids / therapeutic use
Humans
Immunosuppressive Agents / therapeutic use
Magnetic Resonance Angiography
Magnetic Resonance Imaging
Prednisolone / therapeutic use
Takayasu Arteritis / complications,  diagnosis*,  drug therapy
Treatment Outcome
Ventricular Function, Left / drug effects
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Immunosuppressive Agents; 446-86-6/Azathioprine; 50-24-8/Prednisolone

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