| Reduced anxiety and depression-like behaviors in mice lacking GABA transporter subtype 1. | |
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MedLine Citation:
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PMID: 17164814 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gamma-aminobutyric acid (GABA) transporter subtype 1 (GAT1), which transports extracellular GABA into presynaptic neurons, plays an important regulatory role in the function of GABAergic systems. However, the contributions of the GAT1 in regulating mental status are not fully understood. In this paper, we observed the behavioral alterations of GAT1 knockout (GAT1(-/-)) mice using several depression- and anxiety-related models (eg, the forced-swimming test and the tail-suspension test for testing depression-related behaviors; the open-field test, the dark-light exploration test, the emergence test, and the elevated plus maze (EPM) test for anxiety-related behaviors). Here we found that GAT1(-/-) mice showed a lower level of depression- and anxiety-like behaviors in comparison to wild-type mice. Furthermore, GAT1(-/-) mice exhibited measurable insensitivity to selected antidepressants and anxiolytics such as fluoxetine, amitriptyline, buspirone, diazepam, and tiagabine in the tail-suspension test and/or the EPM test. Moreover, the basal level of corticosterone was found to be significantly lower in GAT1(-/-) mice. These results showed that the absence of GAT1 affects mental status through enhancing the GABAergic system, as well as modifying the serotonergic system and the hypothalamic-pituitary-adrenal (HPA) activity in mice. |
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Authors:
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Guo-Xiang Liu; Guo-Qiang Cai; You-Qing Cai; Zhe-Jin Sheng; Jie Jiang; Zhengtong Mei; Zhu-Gang Wang; Lihe Guo; Jian Fei |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-12-13 |
Journal Detail:
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Title: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Volume: 32 ISSN: 0893-133X ISO Abbreviation: Neuropsychopharmacology Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-14 Completed Date: 2007-08-31 Revised Date: 2011-05-18 |
Medline Journal Info:
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Nlm Unique ID: 8904907 Medline TA: Neuropsychopharmacology Country: United States |
Other Details:
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Languages: eng Pagination: 1531-9 Citation Subset: IM |
Affiliation:
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Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Model Organism Research Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Anxiety Agents / pharmacology Antidepressive Agents / pharmacology Anxiety Disorders / genetics, metabolism*, physiopathology Behavior, Animal / physiology Brain / metabolism*, physiopathology Brain Chemistry / genetics Corticosterone / blood, secretion Depressive Disorder / genetics, metabolism*, physiopathology Drug Resistance / genetics Female GABA Plasma Membrane Transport Proteins / deficiency, genetics* Hypothalamo-Hypophyseal System / metabolism, physiopathology, secretion Male Mice Mice, Inbred C57BL Mice, Knockout Neuropsychological Tests Serotonin / metabolism Stress, Psychological / metabolism, physiopathology gamma-Aminobutyric Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Anxiety Agents; 0/Antidepressive Agents; 0/GABA Plasma Membrane Transport Proteins; 50-22-6/Corticosterone; 50-67-9/Serotonin; 56-12-2/gamma-Aminobutyric Acid |
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