| Reduced antioxidant defense capacity in myocardial tissue from guinea pigs treated with 5-fluorouracil. | |
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MedLine Citation:
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PMID: 10777249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antioxidant defense capacity was investigated in myocardial tissue from guinea pigs treated with 5-fluorouracil (5-FU) at a dose of 400 mg/kg/d daily for 5 d administered intraperitonally. Treatment with 5-FU lowered the activities of cardiac superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) accompanied by higher catalase (CAT) activity. Further, antioxidant potential (AOP) values were lower but oxidation resistance (OR) and malondialdehyde (MDA) levels were higher in the 5-FU-treated tissue. With regard to myocardial iron (Fe) and copper (Cu) levels, no significant differences were found between the groups. Results suggest that 5-FU treatment causes impairment in the myocardial antioxidant defense system and leads to cardiac peroxidation. It has been postulated that these changes might be responsible for the 5-FU cardiotoxicity seen in some patients, and antioxidant therapy might provide a therapeutic advantage. |
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Authors:
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I Durak; M Karaayvaz; M Kavutcu; M Y Cimen; M Kaçmaz; S Büyükkoçak; H S Oztürk |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of toxicology and environmental health. Part A Volume: 59 ISSN: 1528-7394 ISO Abbreviation: J. Toxicol. Environ. Health Part A Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-04-27 Completed Date: 2000-04-27 Revised Date: 2006-02-16 |
Medline Journal Info:
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Nlm Unique ID: 100960995 Medline TA: J Toxicol Environ Health A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 585-9 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Ankara University Medical Faculty, Turkey. durak@dialup.ankara.edu.tr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antimetabolites / administration & dosage, pharmacology* Antioxidants / metabolism* Catalase / metabolism Copper / blood Female Fluorouracil / administration & dosage, pharmacology* Glutathione Peroxidase / metabolism Guinea Pigs Heart / drug effects Injections, Intraperitoneal Iron / blood Malondialdehyde / blood Myocardium / enzymology, metabolism* Superoxide Dismutase / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antimetabolites; 0/Antioxidants; 51-21-8/Fluorouracil; 542-78-9/Malondialdehyde; 7439-89-6/Iron; 7440-50-8/Copper; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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