Document Detail

Reduced anterior cingulate glutamatergic concentrations in childhood OCD and major depression versus healthy controls.
MedLine Citation:
PMID:  15322418     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine in vivo glutamatergic neurochemical alterations in the anterior cingulate cortex of pediatric patients with obsessive-compulsive disorder (OCD) without major depressive disorder (MDD) versus pediatric patients with MDD without OCD and healthy controls. METHOD: Single-voxel proton magnetic resonance spectroscopic examinations of the anterior cingulate cortex were conducted in 14 psychotropic-naïve children and adolescents with MDD without OCD, 10 to 19 years of age, 14 case-matched healthy controls, and 20 nondepressed, psychotropic-naïve pediatric patients with OCD 7 to 19 years of age. RESULTS: Anterior cingulate glutamatergic concentrations were significantly reduced in both patients with OCD (15.1% decrease) and patients with MDD (18.7% decrease) compared with controls. Anterior cingulate glutamatergic concentrations did not differ significantly between patients with OCD and those with MDD. CONCLUSIONS: Altered anterior cingulate glutamatergic neurotransmission may be involved in the pathogenesis of OCD and MDD. These preliminary findings further suggest that reduced anterior cingulate glutamate does not differentiate pediatric patients with OCD from pediatric patients with MDD.
David R Rosenberg; Yousha Mirza; Aileen Russell; Jennifer Tang; Janet M Smith; S Preeya Banerjee; Rashmi Bhandari; Michelle Rose; Jennifer Ivey; Courtney Boyd; Gregory J Moore
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American Academy of Child and Adolescent Psychiatry     Volume:  43     ISSN:  0890-8567     ISO Abbreviation:  J Am Acad Child Adolesc Psychiatry     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-23     Completed Date:  2004-12-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8704565     Medline TA:  J Am Acad Child Adolesc Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1146-53     Citation Subset:  IM    
Copyright Information:
Copyright 2004 American Academy of Child and Adolescent Psychiatry
Departments of Psychiatry, Wayne State University, Detroit, MI, USA.
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MeSH Terms
Aspartic Acid / analogs & derivatives*,  metabolism
Choline / metabolism
Creatine / metabolism
Depressive Disorder, Major / diagnosis,  physiopathology*
Glutamic Acid / metabolism*
Glutamine / metabolism*
Gyrus Cinguli / physiopathology*
Inositol / metabolism
Magnetic Resonance Imaging*
Magnetic Resonance Spectroscopy*
Obsessive-Compulsive Disorder / diagnosis,  physiopathology*
Personality Assessment
Phosphocreatine / metabolism
Reference Values
Synaptic Transmission / physiology*
Grant Support
Reg. No./Substance:
56-84-8/Aspartic Acid; 56-85-9/Glutamine; 56-86-0/Glutamic Acid; 57-00-1/Creatine; 62-49-7/Choline; 67-07-2/Phosphocreatine; 6917-35-7/Inositol; 997-55-7/N-acetylaspartate

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