Document Detail

Reduced allergy rates in atopic eczema to contact allergens used in both skin products and foods: atopy and the 'hapten-atopy hypothesis'.
MedLine Citation:
PMID:  18279153     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Food allergy is strongly associated with atopy. This retrospective study investigates whether atopic status affects responses to contact allergens also found in food. We compared incidences of atopic dermatitis/eczema (AD) in subjects who were patch-test positive (PT+) to diallyl disulfide from handling garlic and parabens used as a skin cream/ointment and food preservative with the incidence in those subjects who were PT+ to chemicals encountered at skin surfaces (lanolin and nickel). RESULTS: 36,658 patients with eczema/dermatitis were patch tested (1980-2006). 10,326 (28.2%) had AD. 13/83 (15.6%) PT+ subjects to diallyl disulfide/garlic had AD (AD/total population versus AD/diallyl disulfide PT+, P = 0.011). 54/239 parabens PT+ had AD (22.6%), while 181/608 lanolin PT+ had AD (29.8%) (P < 0.05). CONCLUSIONS: Contact allergy to haptens with oral and skin exposure is reduced in AD compared with non-AD, unlike food protein hypersensitivity. Lanolin frequency was not decreased. Possible explanations include (i) confounding factors, e.g. AD subjects handle garlic less than non-AD subjects, or (ii) AD patients tolerate haptens efficiently, secondary to their atopic status, or (iii) oral tolerance of haptens antagonizes tolerance of food proteins, contributing to development of atopy (hapten-atopy hypothesis). The recent upsurge of atopy took place when gut exposure to haptens in processed foods increased dramatically.
John P McFadden; Jonathan M L White; David A Basketter; Ian Kimber
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Contact dermatitis     Volume:  58     ISSN:  1600-0536     ISO Abbreviation:  Contact Derm.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-18     Completed Date:  2008-03-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  156-8     Citation Subset:  IM    
Department of Cutaneous Allergy, St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, UK.
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MeSH Terms
Allergens / adverse effects
Allyl Compounds / adverse effects
Cosmetics / adverse effects
Databases, Factual
Dermatitis, Atopic / complications*,  immunology
Disulfides / adverse effects
England / epidemiology
Food Hypersensitivity / complications,  epidemiology*
Food Preservatives / adverse effects
Garlic / adverse effects
Haptens / immunology
Medical Records
Nickel / adverse effects
Patch Tests
Retrospective Studies
Reg. No./Substance:
0/Allergens; 0/Allyl Compounds; 0/Cosmetics; 0/Disulfides; 0/Food Preservatives; 0/Haptens; 2179-57-9/diallyl disulfide; 7440-02-0/Nickel

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