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Reduced adipose tissue macrophage content is associated with improved insulin sensitivity in thiazolidinedione-treated diabetic humans.
MedLine Citation:
PMID:  23349486     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Obesity is associated with increased adipose tissue macrophage (ATM) infiltration, and rodent studies suggest that inflammatory factors produced by ATMs contribute to insulin resistance and type 2 diabetes mellitus. However, a relationship between ATM content and insulin resistance has not been clearly established in humans. Since thiazolidinediones attenuate adipose tissue inflammation and improve insulin sensitivity, we examined the temporal relationship of pioglitazone's effects on these two parameters. The impact of 10 and 21 days of pioglitazone treatment on insulin sensitivity in 26 diabetic subjects was assessed by hyperinsulinemic-euglycemic clamp studies. Since chemoattractant factors, cytokines, and immune cells have been implicated in regulating the recruitment of ATMs, we studied their temporal relationship to changes in ATM content.Improved hepatic and peripheral insulin sensitivity was seen after 21 days of pioglitazone. We found early reductions in macrophage chemoattractant factors after only 10 days of pioglitazone, followed by a 69% reduction in ATM content at 21 days and reduced ATM activation at both time points. .While markers for dendritic cells and neutrophils were reduced at both time points, there were no significant changes in regulatory T cells (Tregs). These results are consistent with an association between adipose macrophage content and systemic insulin resistance in humans.
Authors:
Meredith A Hawkins; Sudha Koppaka; Sylvia Kehlenbrink; Weijie Li; Kehao Zhang; Elizabeth Sanchez; Do-Eun Lee; Hanna Lee; Emilce Carrasco; Preeti Kishore; Michelle Carey; Julie Chen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Diabetes     Volume:  -     ISSN:  1939-327X     ISO Abbreviation:  Diabetes     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372763     Medline TA:  Diabetes     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Albert Einstein College of Medicine, Endocrinology, Belfer 701, 1300 Morris Park Avenue, Bronx, New York, United States.
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