Document Detail


Reduced UV-induced degradation of doxorubicin encapsulated in polyethyleneglycol-coated liposomes.
MedLine Citation:
PMID:  10397603     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The aim of this study was to investigate the stability of doxorubicin encapsulated in polyethyleneglycol-coated liposomes (Doxil) under UV-A light. METHODS: High performance liquid chromatography and a fluorimetric method were used to quantify doxorubicin in bulk solution and doxorubicin in Doxil formulation. RESULTS: The photodegradation of Doxil was significantly lower in comparison to the photodegradation of the free drug and showed no concentration dependency at the measured concentration range of 5-50 microg/ml. During and after UV-A irradiation, there was no leakage of the drug from liposomes to the medium. After induced leakage of doxorubicin from the liposomes by the ionophore nigericin, the degradation kinetics of Doxil were identical to that of free doxorubicin. CONCLUSIONS: High intraliposomal doxorubicin concentration and intraliposomal acidic pH are the two critical factors that protect DXR in Doxil from UV-A degradation.
Authors:
S Bandak; A Ramu; Y Barenholz; A Gabizon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmaceutical research     Volume:  16     ISSN:  0724-8741     ISO Abbreviation:  Pharm. Res.     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-08-18     Completed Date:  1999-08-18     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  8406521     Medline TA:  Pharm Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  841-6     Citation Subset:  IM    
Affiliation:
Sharet Institute of Oncology, Hadassah Hebrew University Medical Center, Jerusalem, Israel. suzan@md2.huji.ac.il
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / metabolism,  radiation effects*
Capsules
Doxorubicin / metabolism,  radiation effects*
Drug Carriers / radiation effects
Liposomes / radiation effects
Phosphatidylethanolamines / chemistry
Polyethylene Glycols / chemistry
Ultraviolet Rays*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Capsules; 0/Drug Carriers; 0/Liposomes; 0/Phosphatidylethanolamines; 0/Polyethylene Glycols; 0/polyethylene glycol-distearoylphosphatidylethanolamine; 23214-92-8/Doxorubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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