| Reduced systolic pressure load decreases cell-cycle activity in the fetal sheep heart. | |
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MedLine Citation:
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PMID: 20484695 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The fetal heart is highly sensitive to changes in mechanical load. We have previously demonstrated that increased cardiac load can stimulate cell cycle activity and maturation of immature cardiomyocytes, but the effects of reduced load are not known. Sixteen fetal sheep were given either continuous intravenous infusion of lactated Ringer solution (LR) or enalaprilat, an angiotensin-converting enzyme inhibitor beginning at 127 days gestational age. After 8 days, fetal arterial pressure in the enalaprilat-infused fetuses (23.8 +/- 2.8 mmHg) was lower than that of control fetuses (47.5 +/- 4.7 mmHg) (P < 0.0001). Although the body weights of the two groups of fetuses were similar, the heart weight-to-body weight ratios of the enalaprilat-infused fetuses were less than those of the LR-infused fetuses (5.6 +/- 0.5 g/kg vs. 7.0 +/- 0.6 g/kg, P < 0.0001). Dimensions of ventricular myocytes were not different between control and enalaprilat-infused fetuses. However, there was a significant decrease in cell cycle activity in both the right ventricle (P < 0.005) and the left ventricle (P < 0.002) of the enalaprilat-infused fetuses. Thus, we conclude a sustained reduction in systolic pressure load decreases hyperplastic growth in the fetal heart. |
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Authors:
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P F O'Tierney; D F Anderson; J J Faber; S Louey; K L Thornburg; G D Giraud |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-05-19 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 299 ISSN: 1522-1490 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-03 Completed Date: 2010-09-08 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R573-8 Citation Subset: IM |
Affiliation:
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Heart Research Center, Oregon Health and Sciences Univ., Portland, OR 97239, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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administration & dosage Animals Antihypertensive Agents / administration & dosage Blood Pressure* / drug effects Carbon Dioxide / blood Cell Cycle* / drug effects Cell Differentiation Cell Size Enalaprilat / administration & dosage Fetal Heart / drug effects, pathology*, physiopathology Fetal Weight Gestational Age Hyperplasia Infusions, Intravenous Myocytes, Cardiac / drug effects, pathology* Oxygen / blood Sheep Systole Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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P01HD34430/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen; 84680-54-6/Enalaprilat |
| Comments/Corrections | |
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