| Reduced Short-Interval Intracortical Inhibition after Eccentric Muscle Damage in Human Elbow Flexor Muscles. | |
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MedLine Citation:
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PMID: 22837166 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The purpose of this study was to use paired-pulse transcranial magnetic stimulation (TMS) to examine the effect of eccentric exercise on short-interval intracortical inhibition (SICI) after damage to elbow flexor muscles. Nine young (22.5 ± 0.6 years, mean ± SD) male subjects performed maximal eccentric exercise of the elbow flexor muscles until maximal voluntary contraction (MVC) force was reduced by ~40%. TMS was performed before, 2 hours after and 2 days after exercise under rest and active (5% MVC) conditions, with motor evoked potentials (MEP) recorded from the biceps brachii (BB) muscle. Peripheral electrical stimulation of the brachial plexus was used to assess maximal M-waves, and paired-pulse TMS with a 3 ms interstimulus interval was used to assess changes in SICI at each time point. The eccentric exercise resulted in a 34% decline in strength (P < 0.001), a 41% decline in resting M-wave (P = 0.01), changes in resting elbow joint angle (10°, P < 0.001), and a shift in the optimal elbow joint angle for force production (18°, P < 0.05) 2 hours after exercise. This was accompanied by impaired muscle strength (27%, P < 0.001) and increased muscle soreness (P < 0.001) 2 days after exercise, which is indicative of muscle damage. When the test MEP amplitudes were matched between sessions, we found that SICI was reduced by 27% in resting and 23% in active biceps brachii muscle 2 hours after exercise. SICI recovered 2 days after exercise when muscle pain and soreness was present, suggesting that DOMS from eccentric exercise does not influence SICI. The change in SICI observed 2 hrs after exercise suggests that eccentric muscle damage has widespread effects throughout the motor system that likely includes changes in motor cortex. |
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Authors:
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Bradley Pitman; John G Semmler |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-26 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Adelaide. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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