Document Detail

Reduced Seminal Concentration of CD45pos Cells after Follicle-Stimulating Hormone Treatment in Selected Patients with Idiopathic Oligoasthenoteratozoospermia.
MedLine Citation:
PMID:  24550984     Owner:  NLM     Status:  PubMed-not-MEDLINE    
The present study evaluated the conventional sperm parameters and the seminal concentration of CD45pos cells (pan-leukocyte marker) of infertile patients with idiopathic oligoasthenoteratozoospermia (OAT). The patients were arbitrarily divided into three groups treated with recombinant follicle-stimulating hormone FSH: α (Group A = 20 patients), recombinant FSH- β (Group B = 20 patients), and highly purified human FSH (Group C = 14 patients). All treated groups achieved a similar improvement of the main sperm parameters (density, progressive motility, and morphology), but only the increase in the percentage of spermatozoa with normal morphology was significant compared to the baseline in all three examined groups. Moreover, all groups had a significant reduction of the seminal concentration of CD45pos cells and of the percentage of immature germ cells. Before and after the treatment, the concentration of CD45pos cells showed a positive linear correlation with the percentage of immature germ cells and a negative correlation with the percentage of spermatozoa with regular morphology. These results demonstrate that treatment with FSH is effective in patients with idiopathic OAT and that there are no significant differences between the different preparations. The novelty of this study is in the significant reduction of the concentration of CD45pos cells observed after the treatment.
Rosita A Condorelli; Aldo E Calogero; Enzo Vicari; Laura Mongioi'; Giovanni Burgio; Rossella Cannarella; Filippo Giacone; Linda Iacoviello; Giuseppe Morgia; Vincenzo Favilla; Sebastiano Cimino; Sandro La Vignera
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Publication Detail:
Type:  Journal Article     Date:  2014-01-14
Journal Detail:
Title:  International journal of endocrinology     Volume:  2014     ISSN:  1687-8337     ISO Abbreviation:  Int J Endocrinol     Publication Date:  2014  
Date Detail:
Created Date:  2014-02-19     Completed Date:  2014-02-19     Revised Date:  2014-02-21    
Medline Journal Info:
Nlm Unique ID:  101516376     Medline TA:  Int J Endocrinol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  372060     Citation Subset:  -    
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