| Reduced Ran expression in Ran(+/-) fibroblasts increases cytokine-stimulated nuclear abundance of the AP-1 subunits c-Fos and c-Jun. | |
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MedLine Citation:
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PMID: 20965183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ran (Ras-related nuclear protein), a Ras family GTPase, is involved in multiple cellular functions, including the regulation of DNA replication, cell cycle progression, nuclear structure formation, RNA processing-exportation, and nuclear protein importation. Ran(+/-) embryonic stem (ES) cells were produced in an attempt to generate Ran null mutant mice. Even after an extremely large number of blastocyst injections, no Ran(+/-) chimeric mice could be generated. Ran(+/-) ES cell-derived fibroblasts showed reduced Ran protein expression, and manifested augmented nuclear abundance of AP-1 factors (c-Jun and c-Fos) upon cytokine stimulation. Our experiments demonstrated that intracellular Ran protein levels controlled the nuclear presence of certain transcription factors, such as c-Fos and c-Jun. |
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Authors:
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Diep Ngoc Thi Pham; Hongyu Luo; Jiangping Wu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-21 |
Journal Detail:
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Title: FEBS letters Volume: 584 ISSN: 1873-3468 ISO Abbreviation: FEBS Lett. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-15 Completed Date: 2010-12-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 4623-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Laboratory of Immunology, Centre hospitalier de l'Université de Montréal (CRCHUM)-Hôpital Notre-Dame, Montreal, Quebec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Basic-Leucine Zipper Transcription Factors / metabolism* Cell Nucleus / drug effects*, metabolism Cytokines / pharmacology* Fibroblasts / drug effects*, metabolism Gene Expression Regulation / drug effects* Mice Protein Subunits / metabolism* Proto-Oncogene Proteins c-fos / metabolism Proto-Oncogene Proteins c-jun / metabolism Transcription Factor AP-1 / metabolism ran GTP-Binding Protein / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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IMH-79565//Canadian Institutes of Health Research; MOP57697//Canadian Institutes of Health Research; MOP69089//Canadian Institutes of Health Research; MOP97829//Canadian Institutes of Health Research; PPP86159//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Basic-Leucine Zipper Transcription Factors; 0/Cytokines; 0/Protein Subunits; 0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 0/Transcription Factor AP-1; EC 3.6.5.2/ran GTP-Binding Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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