Document Detail

Reduced Opioid Consumption and Improved Early Rehabilitation with Local and Intraarticular Cocktail Analgesic Injection in Total Hip Arthroplasty: A Randomized Controlled Clinical Trial.
MedLine Citation:
PMID:  21266004     Owner:  NLM     Status:  Publisher    
Objective.  Postoperative pain after total hip arthroplasty (THA) is not well tolerated. We assessed postoperative pain relief and the need for opioid use after using a cocktail of local and intraarticular analgesic injection (LIA) after THA. Methods.  Eighty patients undergoing THA under spinal anesthesia were randomly assigned to receive either LIA or placebo. The LIA was composed of 5 mg morphine, 30 mg bupivacaine (15 mg/1.5 mL), 1 mL betamethasone, and 0.5 mL epinephrine (1:1,000) intraoperatively. We compared three outcomes total morphine consumption, visual analog scale (VAS) at rest and during activity, and hip flexion angle while standing. Results.  When compared with placebo, opioid consumption was significantly reduced in the trial group, as well as VAS at rest and during mobilization. Earlier rehabilitation and better range of motion (ROM) were achieved in the trial group. There were no significant differences in side effects or postoperative wound healing between groups. Conclusion.  In patients undergoing THA, LIA may reduce postoperative systemic opioid use and offer better pain control and earlier rehabilitation, without observable risks.
Wei Liu; Ruijun Cong; Xiaohua Li; Yuli Wu; Haishan Wu
Related Documents :
18203084 - Treatment carryover impacts on effectiveness of intraocular pressure lowering agents, e...
9775234 - Is the single use of intraoperative 5-fluorouracil in filtering surgery for high-risk c...
11864894 - Mode of presentation and time to treatment of uveal melanoma in finland.
19854514 - Natural history of open-angle glaucoma.
18171254 - Clinical and parasite species risk factors for pentavalent antimonial treatment failure...
16594204 - Disease modifying treatment for feline rheumatoid arthritis.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-25
Journal Detail:
Title:  Pain medicine (Malden, Mass.)     Volume:  -     ISSN:  1526-4637     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100894201     Medline TA:  Pain Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Wiley Periodicals, Inc.
Department of Orthopaedics, Changzheng Hospital, Shanghai, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Does Intrathecal Morphine Sulfate Provide Preemptive Analgesia for Patients Undergoing Stapled Hemor...
Next Document:  Chronic Pain and Psychiatric Morbidity: A Comparison between Patients Attending Specialist Orthopedi...