Document Detail

Reduced infant lung function, active smoking, and wheeze in 18-year-old individuals.
MedLine Citation:
PMID:  23420147     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To test the hypothesis that reduced lung function in early life is associated with increased risk for persistent wheeze at age 18 years.
DESIGN: Birth cohort study.
SETTING: Perth, Western Australia.
PARTICIPANTS: Individuals followed up from age 1 month to 18 years.
MAIN OUTCOME MEASURES: Maximal flow at functional residual capacity (V'maxFRC) was measured in 1-month-old infants who were followed up at ages 6, 12, and 18 years. Based on reported symptoms, individuals were categorized as having remittent wheeze, later-onset wheeze, persistent wheeze, and no wheeze. Smoking status was noted at age 18 years.
RESULTS: Of the 253 individuals originally recruited, 150 were followed up at age 18 years; 37 of the 150 had recent wheeze. Compared with the no-wheeze group (n = 96), persistent wheeze (n = 13) was independently associated with reduced percentage of predicted V'maxFRC (mean reduction, 43%; 95% CI, 13-74). Compared with the no-wheeze group, persistent wheeze was also associated with atopy in infancy (odds ratio = 7.1; 95% CI, 1.5-34.5), maternal asthma (odds ratio = 6.8; 95% CI, 1.4-32.3), and active smoking (odds ratio = 4.8; 95% CI, 1.0-21.3). When only wheeze at age 18 years was considered, reduced percentage of predicted V'maxFRC was associated with wheeze at age 18 years only among current smokers (P = .04).
CONCLUSIONS AND RELEVANCE: Wheeze persisting from ages 6 to 18 years is associated with multiple factors, including reduced infant lung function, infant-onset atopy, maternal asthma, and active smoking. Wheeze at age 18 years (regardless of previous wheeze status) is associated with active smoking, but only among those with reduced lung function in infancy. These findings give unique insight into the cause of obstructive airways disease in 18-year-olds, and follow-up of this cohort might be expected to further extend our understanding.
David Mullane; Steve W Turner; Des W Cox; Des Cox; Jack Goldblatt; Lou I Landau; Peter N le Souëf
Related Documents :
24456687 - Research gaps in the demography of aging with disability.
23015287 - Reproductive ecology of female chimpanzees.
23930747 - The slope of change: an environmental management approach to reduce drinking on a day o...
25027507 - Fruit and vegetable consumption of u.s. youth, 2009-2010.
21920077 - Atherosclerotic lesions in the thoracic aorta: a south african anatomical and histologi...
9680237 - Paradigms of retirement: the importance of health and ageing in the whitehall ii study.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  JAMA pediatrics     Volume:  167     ISSN:  2168-6211     ISO Abbreviation:  JAMA Pediatr     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-02     Completed Date:  2013-06-24     Revised Date:  2013-10-25    
Medline Journal Info:
Nlm Unique ID:  101589544     Medline TA:  JAMA Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  368-73     Citation Subset:  AIM; IM    
Department of Paediatrics and Child Health, University College Cork, Cork, Ireland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age of Onset
Follow-Up Studies
Functional Residual Capacity
Logistic Models
Lung / physiology*
Respiratory Function Tests
Respiratory Sounds / physiopathology*
Smoking / physiopathology*
Comment In:
JAMA Pediatr. 2013 Apr;167(4):394-5   [PMID:  23420132 ]
Erratum In:
JAMA Pediatr. 2013 Sep;167(9):873
Note: Cox, Des [corrected to Cox, Des W]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Serum tumor markers and PET/CT imaging for tumor recurrence detection.
Next Document:  Carotid body paragangliomas: a systematic study on management with surgery and radiotherapy.