Document Detail


Reduced IL-1Ra/IL-1 ratio in ultraviolet B-exposed skin of patients with polymorphic light eruption.
MedLine Citation:
PMID:  19046297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Polymorphic light eruption (PLE) is a putative delayed-type allergic reaction to (solar) ultraviolet (UV) exposure. Inadequate immune suppression after UVB-induced sunburn appears to be associated with reduced trafficking of Langerhans cells (LCs) out of and neutrophils into the epidermis of patients sensitive to UVB provocation of PLE. Therefore, we investigated whether pro-inflammatory and chemotactic cytokines are differentially expressed in UVB-irradiated skin of UVB-provocable PLE patients (n = 6) and age- and gender-matched healthy controls (n = 6). Interstitial interleukin-1alpha (IL-1alpha), IL-1beta, IL-1Ra, IL-4, IL-8, tumor necrosis factor-alpha (TNF-alpha), macrophage inflammatory protein 1-alpha (MIP-1alpha), MIP-1beta and monocyte chemotactic protein-1 (MCP-1) were measured in suction blister fluid raised 16 h after exposure to 0, three and six minimal erythemal UVB doses. In unirradiated skin, the IL-1Ra levels were significantly lower in the PLE patients than in controls (P < 0.05). IL-8 and TNF-alpha levels increased strongly upon UVB irradiation in both groups. No differential shifts in cytokine profiles were found that could explain a reduced trafficking of Langerhans cells and neutrophils in PLE patients. Dose-trend analyses showed that UVB irradiation caused significant increases in IL-1alpha in both groups, and that the levels of IL-1alpha and IL-1beta were on average twofold higher in the PLE group (P = 0.03 and P = 0.004, respectively.). Accordingly, the ratios of IL-1Ra over IL-1alpha and over IL-1beta were overall lower in the skin of PLE patients (P = 0.015 and P < 0.001, respectively.). This shift in cytokines in UVB-irradiated skin of PLE patients reveals an amplified early pro-inflammatory cytokine response, which may contribute to the allergic reaction to UVB radiation.
Authors:
A S Janssens; S Pavel; C P Tensen; M B M Teunissen; J J Out-Luiting; R Willemze; F R de Gruijl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-22
Journal Detail:
Title:  Experimental dermatology     Volume:  18     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-04-29     Completed Date:  2009-08-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  212-7     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Cell Movement / radiation effects
Female
Humans
Interleukin 1 Receptor Antagonist Protein / metabolism*
Interleukin-1 / metabolism*
Interleukin-1alpha / metabolism
Interleukin-1beta / metabolism
Interleukin-8 / metabolism
Langerhans Cells / pathology,  radiation effects
Male
Middle Aged
Neutrophils / pathology,  radiation effects
Photosensitivity Disorders / metabolism*,  pathology
Skin / metabolism*,  radiation effects*
Tumor Necrosis Factor-alpha / metabolism
Ultraviolet Rays*
Chemical
Reg. No./Substance:
0/Interleukin 1 Receptor Antagonist Protein; 0/Interleukin-1; 0/Interleukin-1alpha; 0/Interleukin-1beta; 0/Interleukin-8; 0/Tumor Necrosis Factor-alpha

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