| Reduced Hippocampal Glutamate-Glutamine Levels in Irritable Bowel Syndrome: Preliminary Findings Using Magnetic Resonance Spectroscopy. | |
| | |
MedLine Citation:
|
PMID: 21502999 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVES:Enhanced stress responsiveness is an important pathophysiological factor in irritable bowel syndrome (IBS), suggesting the presence of a dysregulated hypothalamic-pituitary-adrenal (HPA) axis. A possible mechanism involves maladaption of the feedback mechanism of the HPA axis. We hypothesized that hippocampus, a key brain region providing inhibitory feedback to the HPA axis, would exhibit reduced excitatory glutamatergic neurotransmission and reduced N-acetyl-aspartate (NAA; a marker of neuronal integrity) levels in IBS patients.METHODS:In this preliminary study, proton magnetic resonance spectroscopy was used to quantify absolute concentrations of metabolites in bilateral hippocampi of 15 IBS patients without significant psychiatric comorbidity and 15 age-matched controls.RESULTS:The main finding was a reduction in hippocampal glutamate-glutamine (Glx) in IBS patients. Furthermore, Glx concentrations were inversely related to emotional stress indicators in patients only. No difference was found between subject groups for other metabolite concentrations, including NAA. However, an elevated myo-inositol (mI)/NAA ratio was found in IBS patients.CONCLUSIONS:Our results provide preliminary evidence for the presence of abnormal hypofunction of hippocampal glutamatergic neurotransmission in IBS patients without psychiatric comorbidity, possibly as a result of the chronic pain. This supports the notion of an imbalance in regulatory brain regions in this subgroup of IBS patients. The inverse relationship between Glx and emotional stress indicators is in agreement with the inhibitory role of hippocampus on the stress system and suggests a sensitization of the mechanism to emotional arousal. The elevated mI/NAA ratio in IBS patients further suggests the presence of hippocampal glial proliferation and remodeling.Am J Gastroenterol advance online publication, 19 April 2011; doi:10.1038/ajg.2011.120. |
| | |
Authors:
|
David M Niddam; Shang-Yueh Tsai; Ching-Liang Lu; Cheng-Wen Ko; Jen-Chuen Hsieh |
Related Documents
:
|
12163289 - Correlation between qt dispersion and burn severity. 1558669 - Clinical studies on postburn multiple organ failure: its aetiological factors and monit... 1395659 - Hypothermia in the sepsis syndrome and clinical outcome. the methylprednisolone severe ... 1951579 - Pudendal neuralgia. 18695609 - Thigh burn associated with laptop computer use. 9295829 - Dramatic effect on oxygenation in patients with severe acute lung insufficiency treated... 11242789 - The significance of perivascular inflammation in the absence of arteritis in temporal a... 7491559 - Streptococcus milleri pulmonary disease: a review and clinical description of 25 patients. 12515449 - Spikes immediately after electroconvulsive therapy in psychotic patients. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-19 |
Journal Detail:
|
Title: The American journal of gastroenterology Volume: - ISSN: 1572-0241 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-19 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1] Brain Research Center, National Yang-Ming University, Taipei, Taiwan, ROC [2] Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan, ROC [3] Department of Medical Research and Education, Laboratory of Integrated Brain Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Adenoma Detection Rate Is Not Influenced by the Timing of Colonoscopy When Performed in Half-Day Blo...
Next Document: Five-Year Analysis of the Prevention of Colorectal Sporadic Adenomatous Polyps Trial.