Document Detail


Reduced DNA-repair capacity in cells originating from a progeria patient.
MedLine Citation:
PMID:  2079964     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A Chinese boy was identified to be suffering from progeria (Hutchinson-Gilford syndrome), the first case of the disease ever reported in China. Cells originating from the patient had a reduced amount of unscheduled DNA synthesis after irradiation with ultraviolet light (UV). The fractions of the progeria cells surviving against UV irradiation measured by colony-forming ability, and the host-cell reactivation capacity of the progeria cells, measured by the plaque formation of UV-irradiated herpes simplex virus were lower than those measured in normal cells. The progeria cells appear to have a reduced capacity to repair UV excision damage.
Authors:
S M Wang; C K Nishigori; J M Zhang; H Takebe
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mutation research     Volume:  237     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:    1990 Sep-Nov
Date Detail:
Created Date:  1991-04-30     Completed Date:  1991-04-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  253-7     Citation Subset:  IM    
Affiliation:
Department of Experimental Radiology, Kyoto University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Cells, Cultured
Child
DNA Repair*
DNA Replication* / radiation effects
Humans
Male
Progeria / genetics*,  pathology
Reference Values
Skin / cytology,  pathology*,  radiation effects
Ultraviolet Rays

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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