| Reduced DNA-repair capacity in cells originating from a progeria patient. | |
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MedLine Citation:
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PMID: 2079964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A Chinese boy was identified to be suffering from progeria (Hutchinson-Gilford syndrome), the first case of the disease ever reported in China. Cells originating from the patient had a reduced amount of unscheduled DNA synthesis after irradiation with ultraviolet light (UV). The fractions of the progeria cells surviving against UV irradiation measured by colony-forming ability, and the host-cell reactivation capacity of the progeria cells, measured by the plaque formation of UV-irradiated herpes simplex virus were lower than those measured in normal cells. The progeria cells appear to have a reduced capacity to repair UV excision damage. |
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Authors:
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S M Wang; C K Nishigori; J M Zhang; H Takebe |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Mutation research Volume: 237 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1990 Sep-Nov |
Date Detail:
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Created Date: 1991-04-30 Completed Date: 1991-04-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 253-7 Citation Subset: IM |
Affiliation:
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Department of Experimental Radiology, Kyoto University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cells, Cultured Child DNA Repair* DNA Replication* / radiation effects Humans Male Progeria / genetics*, pathology Reference Values Skin / cytology, pathology*, radiation effects Ultraviolet Rays |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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