| Reduced CSF CART in dementia with Lewy bodies. | |
| | |
MedLine Citation:
|
PMID: 19356602 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). The underlying neurobiological mechanism of DLB is not fully understood and no generally accepted biomarkers are yet available for the diagnosis of DLB. In a recent MRI study, DLB patients displayed hypothalamic atrophy whereas this region was not affected in AD patients. Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed selectively in neurons in the hypothalamus. Here, we found that CSF CART levels were significantly reduced by 30% in DLB patients (n = 12) compared to controls (n = 12) as well as to AD patients (n = 14) using radioimmunoassay. Our preliminary results suggest that reduced CSF CART is a sign of hypothalamic dysfunction in DLB and that it may serve as a biomarker for this patient group. |
| | |
Authors:
|
Kristofer Schultz; Sara Wiehager; Karin Nilsson; Jørgen E Nielsen; Suzanne G Lindquist; Lena E Hjermind; Birgitte B Andersen; Anders Wallin; Christer Nilsson; Asa Petersén |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-02-10 |
Journal Detail:
|
Title: Neuroscience letters Volume: 453 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2009 Apr |
Date Detail:
|
Created Date: 2009-04-09 Completed Date: 2009-06-12 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
|
Languages: eng Pagination: 104-6 Citation Subset: IM |
Affiliation:
|
Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Alzheimer Disease / cerebrospinal fluid*, diagnosis Amyloid beta-Protein / cerebrospinal fluid Analysis of Variance Female Humans Lewy Body Disease / cerebrospinal fluid*, diagnosis Male Nerve Tissue Proteins / cerebrospinal fluid* Peptide Fragments / cerebrospinal fluid Radioimmunoassay tau Proteins / cerebrospinal fluid |
| Chemical | |
Reg. No./Substance:
|
0/Amyloid beta-Protein; 0/Nerve Tissue Proteins; 0/Peptide Fragments; 0/cocaine- and amphetamine-regulated transcript protein; 0/tau Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neuroprotective effect of alpha-asarone on spatial memory and nitric oxide levels in rats injected w...
Next Document: Electrophysiology reveals semantic priming at a short SOA irrespective of depth of prime processing.