Document Detail


Reduced CSF CART in dementia with Lewy bodies.
MedLine Citation:
PMID:  19356602     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). The underlying neurobiological mechanism of DLB is not fully understood and no generally accepted biomarkers are yet available for the diagnosis of DLB. In a recent MRI study, DLB patients displayed hypothalamic atrophy whereas this region was not affected in AD patients. Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed selectively in neurons in the hypothalamus. Here, we found that CSF CART levels were significantly reduced by 30% in DLB patients (n = 12) compared to controls (n = 12) as well as to AD patients (n = 14) using radioimmunoassay. Our preliminary results suggest that reduced CSF CART is a sign of hypothalamic dysfunction in DLB and that it may serve as a biomarker for this patient group.
Authors:
Kristofer Schultz; Sara Wiehager; Karin Nilsson; Jørgen E Nielsen; Suzanne G Lindquist; Lena E Hjermind; Birgitte B Andersen; Anders Wallin; Christer Nilsson; Asa Petersén
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-10
Journal Detail:
Title:  Neuroscience letters     Volume:  453     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-09     Completed Date:  2009-06-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  104-6     Citation Subset:  IM    
Affiliation:
Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / cerebrospinal fluid*,  diagnosis
Amyloid beta-Protein / cerebrospinal fluid
Analysis of Variance
Female
Humans
Lewy Body Disease / cerebrospinal fluid*,  diagnosis
Male
Nerve Tissue Proteins / cerebrospinal fluid*
Peptide Fragments / cerebrospinal fluid
Radioimmunoassay
tau Proteins / cerebrospinal fluid
Chemical
Reg. No./Substance:
0/Amyloid beta-Protein; 0/Nerve Tissue Proteins; 0/Peptide Fragments; 0/cocaine- and amphetamine-regulated transcript protein; 0/tau Proteins

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