| Reduced anisotropy in the middle cerebellar peduncle in Chiari-II malformation. | |
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MedLine Citation:
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PMID: 20191336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Besides supratentorial abnormalities, spina bifida menigomyelocele (SBM) is typically associated with Chiari-II malformation comprising a small cerebellum, which herniates downward due to a shallow posterior fossa. We used diffusion tensor imaging to probe additional microstructural alterations of the major cerebellar white matter tracts, the cerebellar peduncles. A region-of-interest approach was employed in six SBM patients and six matched controls to compare the fractional anisotropy (FA) within the superior, middle, and inferior cerebellar peduncle (SCP, MCP, and ICP, respectively). The FA in the MCP was significantly reduced in the SBM patients (0.44 vs. 0.65, p = 0.002), while there was no significant difference in the other cerebellar peduncles. In the context of numerous supratentorial white matter abnormalities in SBM such as callosal dysplasia, the most likely explanation of reduced FA in the MCP is a reduced fiber density. |
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Authors:
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Christian Herweh; Michael Akbar; Martina Wengenroth; Sabine Heiland; Martin Bendszus; Christoph Stippich |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cerebellum (London, England) Volume: 9 ISSN: 1473-4230 ISO Abbreviation: Cerebellum Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-10-05 Completed Date: 2011-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101089443 Medline TA: Cerebellum Country: United States |
Other Details:
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Languages: eng Pagination: 303-9 Citation Subset: IM |
Affiliation:
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Department of Neuroradiology, Heidelberg Medical School, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany. christian_herweh@med.uni-heidelberg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anisotropy Arnold-Chiari Malformation / complications, pathology Cerebellum / pathology* Diffusion Tensor Imaging Female Humans Male Meningomyelocele / complications, pathology Young Adult |
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